| African sprinter | 16 |
| African spread | 14 |
| African spirit | 14 |
| African spears | 14 |
| African spear: Var. | 19 |
| African spear | 13 |
| African sorcery | 15 |
| African sorceress of fiction | 28 |
| African soldier | 15 |
| African soccer powerhouse popularly known as the Black Stars | 60 |
| African snapper | 15 |
| African snakes | 14 |
| African snake | 13 |
| African slitherer | 17 |
| African sleep-inducer | 21 |
| African skunk | 13 |
| African shrub in the lily family | 32 |
| African shrub | 13 |
| African sheep | 13 |
| African serpents | 16 |
| African serpent | 15 |
| African secret society | 22 |
| African secessionist state: 1967-70 | 35 |
| African seceder of 1993 | 23 |
| African scourge | 15 |
| African scavengers | 18 |
| African scavenger | 17 |
| African sands | 13 |
| African salt bed | 16 |
| African runner | 14 |
| African ruminant | 16 |
| African rulers | 14 |
| African ruler? | 14 |
| African ruler | 13 |
| African rodent | 14 |
| African robe at the U.N. | 24 |
| African roarer | 14 |
| African river that's the world's deepest | 48 |
| African river that two capitals are on | 38 |
| African river that runs through ten countries | 45 |
| African river or land | 21 |
| African river or lake | 21 |
| African river or Italian physicist | 34 |
| African river or country | 24 |
| African river on Saint-Exupéry's journey | 47 |
| African river featuring Victoria Falls | 38 |
| African river | 13 |
| African republic: Fr. | 21 |
| African republic with the motto "Victory is ours" | 59 |
| African republic or lake | 24 |
| African republic inhabitant | 27 |
| African republic colonized by freed American slaves | 51 |
| African republic (formerly) | 27 |
| African republic | 16 |
| African reptiles | 16 |
| African region totaling 1.2 million square miles | 48 |
| African region including Khartoum and Timbuktu | 46 |
| African region | 14 |
| African reedbucks | 17 |
| African reed instruments | 24 |
| African ravines | 15 |
| African ravine | 14 |
| African raptor | 14 |
| African ranger | 14 |
| African range rovers | 20 |
| African range | 13 |
| African queen of old, familiarly | 32 |
| African Queen e.g. | 22 |
| African pullover | 16 |
| African province | 16 |
| African primate | 15 |
| African president's tenure? | 31 |
| African predator | 16 |
| African prairies | 16 |
| African prairie | 15 |
| African potentate | 17 |
| African port of 2.2 million | 27 |
| African port | 12 |
| African political movement | 26 |
| African point, or Dracula's cloak of optimism? | 50 |
| African plateau area | 20 |
| African plateau | 15 |
| African plants, informally | 26 |
| African plants | 14 |
| African plant whose leaves are chewed as a stimulant | 52 |
| African plant | 13 |
| African plains grazers | 22 |
| African plains grazer | 21 |
| African plain | 13 |
| African pests | 13 |
| African pest | 12 |
| African people: Var. | 20 |
| African people | 14 |
| African peninsula | 17 |
| African pen | 11 |
| African peak | 12 |
| African pastureland | 19 |
| African pastoral people | 23 |
| African parasite | 16 |
| African palms | 13 |