| Ingredient for making gunpowder during Passover? | 48 |
| It's a long way from John o' Groat's | 48 |
| Item used to fasten planks, in old ship building | 48 |
| Is dramatically revealed to, with "at" | 48 |
| Ilsa's maiden name in "Casablanca" | 48 |
| Ingredient you shouldn't use to make quiche? | 48 |
| Italian physician and educator: 1870–1952 | 48 |
| It followed "hey" in Elizabethan times | 48 |
| Italy's "City of a Hundred Towers" | 48 |
| It's seen on workers just above the beltline | 48 |
| IBM/Apple product starting in the early '90s | 48 |
| It led to the first anti-aircraft missile system | 48 |
| International alliance dissolved in 1977 (abbr.) | 48 |
| Incredulous response to an improbable accusation | 48 |
| It was India's summer capital during the Raj | 48 |
| In cahoots w/Warner or Elektra at various points | 48 |
| iPhone 4S program that recognizes voice commands | 48 |
| Impending event that causes supermarket crowding | 48 |
| Ian and Sylvia hit "Lovin' ______" | 48 |
| It may have a ''HOT STOCK TIP!'' | 48 |
| It's in the kitchen, perhaps with a potbelly | 48 |
| It can be twisted and flicked to make a loud pop | 48 |
| It's when the ``livin' is easy'' | 48 |
| Its flag has a yellow cross on a blue background | 48 |
| It might fill your eye during a sentimental song | 48 |
| It fell on Taylor Swift's "Guitar" | 48 |
| It follows "high" or "Texas" | 48 |
| Its middle letter stands for a city in Tennessee | 48 |
| It may display the latest innovations in a field | 48 |
| It's better known for its bark than its bite | 48 |
| It's at about 9800 feet on Mount Kilimanjaro | 48 |
| It went "Up, up, ..." and away in 2001 | 48 |
| Its first letter stands for "untersee" | 48 |
| Instruments that may be made from monkeypod wood | 48 |
| Intl. grp. for which 47A was named an ambassador | 48 |
| Indicator that you're back to your own words | 48 |
| Its slogan was once "Above all": Abbr. | 48 |
| It joins I-10 in Jacksonville and I-90 in Boston | 48 |
| It went "where no man has gone before" | 48 |
| It's often not needed for hors d'oeuvres | 48 |
| Instrument heard in "Dust in the Wind" | 48 |
| Insect that can control the sex of its offspring | 48 |
| It was big for everyone to have one in the 1990s | 48 |
| Important parts of the body's defense system | 48 |
| Imposing monetary penalties with a nice Chianti? | 48 |
| It has counties named Lincoln and Douglas: Abbr. | 48 |
| Indie band with many a New Jersey-themed release | 48 |
| Isaac's best friend in "Manhattan" | 48 |
| It might have the heading "Vacuum-Van" | 48 |
| Irving Berlin's "___ Be Surprised" | 48 |
| Instrument used to score “The Third Man” | 48 |
| Indication that one is being rubbed the right way | 49 |
| It starts with "Marley was dead . . . " | 49 |
| It ends with Lear heading out into stormy weather | 49 |
| It traditionally translates to "O come" | 49 |
| Image in the center of Armenia's coat of arms | 49 |
| It's detected by the Marsh test, in forensics | 49 |
| Its coat of arms includes a marlin and a flamingo | 49 |
| Island of the Bahamas whose capital is Alice Town | 49 |
| It might come straight from the horse's mouth | 49 |
| Italian city after which a deli offering is named | 49 |
| In a ___, there's no shortage of ___ to drink | 49 |
| It's often turned upside down when not in use | 49 |
| Instrument named for its similarity to a chestnut | 49 |
| It's often flavored with vanilla and cinnamon | 49 |
| It's for those who can't handle the truth | 49 |
| Its website has a "Rodents 101" section | 49 |
| Insecticide whose spelled-out name has 31 letters | 49 |
| If it's outstanding, it's really not good | 49 |
| It was Genentech's stock ticker symbol, aptly | 49 |
| It's been extinct since the late 17th century | 49 |
| Island discovered on Columbus's second voyage | 49 |
| It starts by "springing forward": abbr. | 49 |
| Israeli statesman born in Cape Town, South Africa | 49 |
| Israel's first United Nations ambassador Abba | 49 |
| Italian author of "The Prague Cemetery" | 49 |
| Ice cream known as Dreyer's on the West Coast | 49 |
| It was established with the Treaty of Rome: Abbr. | 49 |
| Inspiration for "The French Connection" | 49 |
| Impersonators grow their sideburns to imitate him | 49 |
| Important considerations in Cy Young Award voting | 49 |
| Its flag features an olive branch inside a wreath | 49 |
| It was first publicly performed in Vienna in 1805 | 49 |
| It rhymes with its preceding and following letter | 49 |
| Import with a "cavallino rampante" logo | 49 |
| It loses to an open hand in rock, paper, scissors | 49 |
| It helps you when you're going places (abbr.) | 49 |
| It has an analytical writing component, for short | 49 |
| Island "where America's day begins" | 49 |
| It's guarded by the three-headed dog Cerberus | 49 |
| It gets pulled out in times of extreme depression | 49 |
| Its national anthem is "Jana Gana Mana" | 49 |
| Its two halves usually aren't the same length | 49 |
| It's between the Missouri and the Mississippi | 49 |
| Its HQ is on Washington's Constitution Avenue | 49 |
| Its literal translation is "submission" | 49 |
| Informal response to "Who's there?" | 49 |
| Its flag is made of green, yellow and red stripes | 49 |
| Its cover is round so it doesn't fall through | 49 |
| Island between La-nai and Molokai, alphabetically | 49 |