| Second half of an audiotape | 27 |
| Second half of an inning | 24 |
| Second half of CLUE #2 | 22 |
| Second half of the quote | 24 |
| Second helping, to a dieter | 27 |
| Second highest peak in N.A. | 27 |
| Second highest pinochle card | 28 |
| Second homes for apparatchiks | 29 |
| Second human on the moon | 24 |
| Second in a certain series | 26 |
| Second in a classical trio | 26 |
| Second in a German series | 25 |
| Second in a Greek series | 24 |
| Second in a Latin series | 24 |
| Second in all-time hits | 23 |
| Second in command, briefly | 26 |
| Second in command, informally | 29 |
| Second in command, maybe | 24 |
| Second in command, often | 24 |
| Second in command: abbr. | 24 |
| Second in court?: Abbr. | 23 |
| Second in the credits, often | 28 |
| Second lady after Tipper | 24 |
| Second largest asteroid | 23 |
| Second largest city in France | 29 |
| Second largest city in Italy | 28 |
| Second largest city in Japan | 28 |
| Second largest European lake | 28 |
| Second largest Great Lake | 25 |
| Second largest lake in Europe | 29 |
| Second largest of seven | 23 |
| Second largest of the seven | 27 |
| Second letter addendum | 22 |
| Second letter addendum: Abbr. | 29 |
| Second letter additions | 23 |
| Second letter after epsilon | 27 |
| Second letter afterthought | 26 |
| Second letter before iota | 25 |
| Second letter from Greece | 25 |
| Second lieutenant, slangily | 27 |
| Second lightest element | 23 |
| Second line of the limerick | 27 |
| Second line of the verse | 24 |
| Second longest African river | 28 |
| Second lt.'s equivalent | 27 |
| Second lt.'s subordinate | 28 |
| Second man off Apollo 11 | 24 |
| Second man on the moon | 22 |
| Second Manassas commander | 25 |
| Second Manassas victor | 22 |
| Second mate's kid? | 22 |
| Second mobster's query | 26 |
| Second mortgages, generally | 27 |
| Second most populated country | 29 |
| Second most populous country | 28 |
| Second NAACP president | 22 |
| Second name in cosmetics | 24 |
| Second name in inventions | 25 |
| Second name in inventors | 24 |
| Second name on the bill | 23 |
| Second New Testament book | 25 |
| Second notes of the scale | 25 |
| Second nursery rhyme tumbler | 28 |
| Second of a Caesarean trio | 26 |
| Second of a cereal trio | 23 |
| Second of a historical trio | 27 |
| Second of a Latin 101 trio | 26 |
| Second of a Latin I trio | 24 |
| Second of a Latin paradigm | 26 |
| Second of a Latin trio | 22 |
| Second of a musical tetralogy | 29 |
| Second of a poetic trio | 23 |
| Second of a restless pair | 25 |
| Second of four at college | 25 |
| Second of six for Henry VIII | 28 |
| Second of three black keys | 26 |
| Second of three virtues | 23 |
| Second of three X's | 23 |
| Second of two bell sounds | 25 |
| Second of two mentioned | 23 |
| Second of two photos, perhaps | 29 |
| Second of two sections | 22 |
| Second of two spouses? | 22 |
| Second offer, as on eBay | 24 |
| Second opening in a sock | 24 |
| Second option's lead-in | 27 |
| Second or sixth in a series | 27 |
| Second or sixth president | 25 |
| Second or tenth, in a way | 25 |
| Second or third showing | 23 |
| Second or third showing, e.g. | 29 |
| Second or third, for instance | 29 |
| Second order of angels | 22 |
| Second page in a chapter | 24 |
| Second part of a sage thought | 29 |
| Second part of a snicker | 24 |
| Second part of the headline | 27 |
| Second part of the joke | 23 |
| Second part of the message | 26 |
| Second part of the question | 27 |