| Drug magnate Lilly | 18 |
| Drug made in labs | 17 |
| Drug made from poppies | 22 |
| Drug made from orchids | 22 |
| Drug made from dried roots | 26 |
| Drug lord Escobar | 17 |
| Drug list: Abbr. | 16 |
| Drug like diazepam | 18 |
| Drug kingpin | 12 |
| Drug introduced commercially in 1945 | 36 |
| Drug initials | 13 |
| Drug initially studied for use in treating angina | 49 |
| Drug info | 9 |
| Drug in William Shatner books | 29 |
| Drug in the den? | 16 |
| Drug in some fabulously misguided episodes of "Dragnet" | 65 |
| Drug in Shatner stories | 23 |
| Drug in Shatner novels | 22 |
| Drug in Kipling story | 21 |
| Drug in a sci-fi novel series | 29 |
| Drug in a Miley Cyrus viral video | 33 |
| Drug in a den | 13 |
| Drug in "Brave New World" | 35 |
| Drug in "Apocalypse Now" | 34 |
| Drug hookups, for short? | 24 |
| Drug holder | 11 |
| Drug given to race horses, for short | 36 |
| Drug giant __SmithKline | 23 |
| Drug giant behind Valium and Klonopin | 37 |
| Drug giant | 10 |
| Drug from the leaves of a plant | 31 |
| Drug from poppies | 17 |
| Drug from Colombia | 18 |
| Drug for the angst-ridden | 25 |
| Drug for Parkinson's patients | 33 |
| Drug for pain | 13 |
| Drug for anxiety | 16 |
| Drug for a poisoning victim | 27 |
| Drug for a poison victim, maybe | 31 |
| Drug fighting infections | 24 |
| Drug enterprises | 16 |
| Drug enforcer | 13 |
| Drug enforcement agts. | 22 |
| Drug enforcement agent | 22 |
| Drug effect, sometimes | 22 |
| Drug drop, maybe | 16 |
| Drug drawback | 13 |
| Drug distributors? | 18 |
| Drug distributor | 16 |
| Drug dispenser | 14 |
| Drug discovered in 1853 | 23 |
| Drug dick | 9 |
| Drug derived from ergot | 23 |
| Drug delivery mode | 18 |
| Drug dealers, slangily | 22 |
| Drug dealers' union? | 24 |
| Drug dealers' foes | 22 |
| Drug dealer's nemesis | 25 |
| Drug dealer's customer | 26 |
| Drug dealer on "The Wire" | 35 |
| Drug czar Kerlikowske | 21 |
| Drug cops, for short | 20 |
| Drug cops | 9 |
| Drug cop, for short | 19 |
| Drug cop | 8 |
| Drug cooked up in labs | 22 |
| Drug connections? | 17 |
| Drug connection? | 16 |
| Drug company, for short | 23 |
| Drug company whose stock was the subject of Martha Stewart's conviction | 75 |
| Drug company that makes Valium | 30 |
| Drug company once headed by Donald Rumsfeld | 43 |
| Drug company giant that makes Coppertone | 40 |
| Drug company founder Lilly | 26 |
| Drug company dept. | 18 |
| Drug company behind Valium | 26 |
| Drug combination? | 17 |
| Drug choice | 11 |
| Drug chain | 10 |
| Drug cartel? | 12 |
| Drug carrier across the border | 30 |
| Drug carrier | 12 |
| Drug called "acid" | 28 |
| Drug busters | 12 |
| Drug buster, for short | 22 |
| Drug buster | 11 |
| Drug bust, e.g. | 15 |
| Drug bust unit | 14 |
| Drug bust participant | 21 |
| Drug bust finds | 15 |
| Drug bust figures | 17 |
| Drug bust figure? | 17 |
| Drug bust cop | 13 |
| Drug bust agents | 16 |
| Drug bust | 9 |
| Drug brand name that combines Latin words | 41 |
| Drug book for MDs | 17 |
| Drug banned in the U.S. in 1967 | 31 |
| Drug banned by most pro sports | 30 |
| Drug available in LiquiCaps | 27 |