| Big palookas | 12 |
| Big palooka | 11 |
| Big pair | 8 |
| Big painting | 12 |
| Big pain for an elephant? | 25 |
| Big pain | 8 |
| Big P&G brand | 17 |
| Big oxygen producer | 19 |
| Big ox, say | 11 |
| Big ox | 6 |
| Big overhead? | 13 |
| Big ornate cabinet | 18 |
| Big org. come April | 19 |
| Big order | 9 |
| Big Orange of college sports | 28 |
| Big or top follower | 19 |
| Big or Little, in the night sky | 31 |
| Big or Little Poison | 20 |
| Big or Little in the sky | 24 |
| Big or little follower | 22 |
| Big or little dipper | 20 |
| Big or little digit | 19 |
| Big or Little | 13 |
| Big or Gentle | 13 |
| Big or full follower | 20 |
| Big or Franklin | 15 |
| Big or bright thing | 19 |
| Big or baby, e.g. | 17 |
| Big operatic ending | 19 |
| Big opening? | 12 |
| Big ones often clash | 20 |
| Big ones can impede progress | 28 |
| Big ones can be chairs | 22 |
| Big ones are often fought over | 30 |
| Big one on the set, perhaps | 27 |
| Big one in parliament | 21 |
| Big one in London | 17 |
| Big one in baseball | 19 |
| Big one | 7 |
| Big on top? | 11 |
| Big on | 6 |
| Big olive oil exporter | 22 |
| Big ol' zeros | 17 |
| Big ol' stumblebum | 22 |
| Big ol' pile | 16 |
| Big ol' nose | 16 |
| Big oil supplier | 16 |
| Big oil source | 14 |
| Big Oil merger of 1998 | 22 |
| Big oil gp. | 11 |
| Big oil exporter | 16 |
| Big oil company, informally | 27 |
| Big oil company, for short | 26 |
| Big oil company | 15 |
| Big oil cartel (abbr.) | 22 |
| Big occasion | 12 |
| Big oafs | 8 |
| Big oaf | 7 |
| Big O.? | 7 |
| Big NYSE influence | 18 |
| Big numismatic news | 19 |
| Big numbers, for short | 22 |
| Big numbers | 11 |
| Big number, slangily | 20 |
| Big number | 10 |
| Big NPR donor Joan | 18 |
| Big nothings | 12 |
| Big nothing | 11 |
| Big note | 8 |
| Big North Carolina industry | 27 |
| Big noise | 9 |
| Big no-nos | 10 |
| Big nip | 7 |
| Big Nintendo plumber? | 21 |
| Big night out | 13 |
| Big night for teens | 19 |
| Big night | 9 |
| Big Nigerian export | 19 |
| Big newsstand seller for some magazines | 39 |
| Big newspapers and magazines, etc. | 34 |
| Big newspaper company, informally | 33 |
| Big news on the sports page | 27 |
| Big news of 1969 | 16 |
| Big news in the 40's and 50's | 37 |
| Big news in sports | 18 |
| Big news in 1945, informally | 28 |
| Big news for a starting business: Abbr. | 39 |
| Big news exclusive | 18 |
| Big New Zealand bird | 20 |
| Big New York contract signer of 2007, to fans | 45 |
| Big New Year's Day events | 29 |
| Big NCAA conference | 19 |
| Big naval group | 15 |
| Big natural history museum attraction | 37 |
| Big Nascar advertiser | 21 |
| Big names of the 1930's | 27 |
| Big names in zoos | 17 |
| Big names in TV | 15 |
| Big names in l'opéra | 27 |
| Big names in intl. orgs. | 24 |