| Big sugar exporter | 18 |
| Big sucker | 10 |
| Big successes | 13 |
| Big success | 11 |
| Big suburban yard | 17 |
| Big Stuf cookie | 15 |
| Big studio release, in the army? | 32 |
| Big striped cat, in Spain | 25 |
| Big striped cat | 15 |
| Big strings | 11 |
| Big stretches | 13 |
| Big stretch? | 12 |
| Big stretch | 11 |
| Big story | 9 |
| Big storm | 9 |
| Big stories | 11 |
| Big store | 9 |
| Big stirs | 9 |
| Big stir | 8 |
| Big stinks | 10 |
| Big stink? | 10 |
| Big stink | 9 |
| Big stingers | 12 |
| Big stinger | 11 |
| Big stickers | 12 |
| Big sticker? | 12 |
| Big stick carrier | 17 |
| Big steps | 9 |
| Big step up from the bleachers | 30 |
| Big step for a pilot-in-training | 32 |
| Big step | 8 |
| Big statue isle | 15 |
| Big stationery letter: Abbr. | 28 |
| Big stat for Manny Ramirez | 26 |
| Big start? | 10 |
| Big start for bucks | 19 |
| Big stars have Grammy ones | 26 |
| Big star, say | 13 |
| Big star, briefly | 17 |
| Big star of early TV | 20 |
| Big star in Carina | 18 |
| Big star at night | 17 |
| Big star | 8 |
| Big stain | 9 |
| Big stack of firewood | 21 |
| Big stack | 9 |
| Big squares | 11 |
| Big spreads | 11 |
| Big spreaders | 13 |
| Big spread, maybe | 17 |
| Big spread | 10 |
| Big spout | 9 |
| Big sports venue | 16 |
| Big sports news | 15 |
| Big sports inits. | 17 |
| Big sports event? | 17 |
| Big sports event sponsor | 24 |
| Big sports event | 16 |
| Big sport's offer | 21 |
| Big sport overseas? | 19 |
| Big sport in Japan | 18 |
| Big splash sites | 16 |
| Big splash maker of the '60s | 32 |
| Big splash at Seaworld | 22 |
| Big splash aftermath? | 21 |
| Big splash | 10 |
| Big spinning effort | 19 |
| Big spinner | 11 |
| Big spenders | 12 |
| Big spender, maybe | 18 |
| Big spender's woe? | 22 |
| Big spender's stash | 23 |
| Big spender's roll | 22 |
| Big spender's phrase | 24 |
| Big spender's opposite | 26 |
| Big spender's offer | 23 |
| Big spender's accessory | 27 |
| Big spender or tipper | 21 |
| Big spender | 11 |
| Big speech maker | 16 |
| Big speech | 10 |
| Big Spanish-language newspaper | 30 |
| Big Spanish celebration | 23 |
| Big Southwestern trombones? | 27 |
| Big Southern department store chain | 35 |
| Big South Conference college | 28 |
| Big South American bird | 23 |
| Big source of state revenue | 27 |
| Big source of reality TV | 24 |
| Big source of corn | 18 |
| Big source of coll. scholarships | 32 |
| Big source of amazement | 23 |
| Big source for modern slang | 27 |
| Big sound | 9 |
| Big song for Lionel Richie | 26 |
| Big solos during death scenes, often | 36 |
| Big soiree | 10 |
| Big soda ___ (NYC public health initiative) | 43 |
| Big social gathering, e.g. | 26 |
| Big social gathering | 20 |