| Big ___ (W.W. I cannon) | 23 |
| Big ___ (Villanova's conference) | 36 |
| Big ___ (V.I.P.) | 16 |
| Big ___ (V.I.P.'s) | 22 |
| Big ___ (universe-origin theory) | 32 |
| Big ___ (top dog) | 17 |
| Big ___ (the drug industry) | 27 |
| Big ___ (State Fair icon displayed in Dallas) | 45 |
| Big ___ (sports conference) | 27 |
| Big ___ (self-important men, in Southern slang) | 47 |
| Big ___ (sandwich) | 18 |
| Big ___ (Rutgers's conference) | 34 |
| Big ___ (pill sellers) | 22 |
| Big ___ (phrase on Montana license plates) | 42 |
| Big ___ (person who takes a date to a fast-food restaurant, jocularly) | 70 |
| Big ___ (OutKast rapper) | 24 |
| Big ___ (nickname of New Orleans) | 33 |
| Big ___ (nickname of baseball's Ortiz) | 42 |
| Big ___ (nickname of baseball's David Ortiz) | 48 |
| Big ___ (nickname of ballplayer David Ortiz) | 44 |
| Big ___ (nickname for David Ortiz of the Red Sox) | 49 |
| Big ___ (NCAA conference) | 25 |
| Big ___ (NCAA conference that actually has eleven teams) | 56 |
| Big ___ (McDonald's sandwich) | 33 |
| Big ___ (large cannon) | 22 |
| Big ___ (hallux) | 16 |
| Big ___ (Half of OutKast) | 25 |
| Big ___ (group of stars in Ursa Major) | 38 |
| Big ___ (Golden Arches offering) | 32 |
| Big ___ (German W.W. I cannon) | 30 |
| Big ___ (German gun in W.W. I) | 30 |
| Big ___ (David Ortiz's nickname) | 36 |
| Big ___ (David Ortiz nickname) | 30 |
| Big ___ (Dallas fair icon) | 26 |
| Big ___ (country rapper with an A&E reality show) | 53 |
| Big ___ (Cornell) | 17 |
| Big ___ (conference that has eleven teams in it) | 48 |
| Big ___ (college sports elite) | 30 |
| Big ___ (circus) | 16 |
| Big ___ (certain energy lobby, pejoratively) | 44 |
| Big ___ (California region) | 27 |
| Big ___ (body part) | 19 |
| Big ___ (baseball's David Ortiz) | 36 |
| Big ___ (André 3000's partner) | 37 |
| Big ___ (André 3000's Outkast partner) | 45 |
| Big ___ ("South Park" character) | 42 |
| Big ___ | 7 |
| Big __: WWI cannon | 18 |
| Big __: Red Sox slugger's nickname | 38 |
| Big __: Red Sox nickname | 24 |
| Big __: nickname for LPGA great JoAnne Carner | 45 |
| Big __: fast-food staple | 24 |
| Big __: baseball's David Ortiz | 34 |
| Big __, California | 18 |
| Big __, Calif. | 14 |
| Big __, CA | 10 |
| Big __ outdoors | 15 |
| Big __ Country (Montana) | 24 |
| Big __ Country | 14 |
| Big __ (NCAA division) | 22 |
| Big __ | 6 |
| Big zoo beast, for short | 24 |
| Big zoo attractions | 19 |
| Big zoo attraction? | 19 |
| Big zoo attraction | 18 |
| Big zoo animal | 14 |
| Big zinc exporter | 17 |
| Big zero Refreshments song? | 27 |
| Big zero | 8 |
| Big yawns | 9 |
| Big yawn | 8 |
| Big yard, perhaps | 17 |
| Big yard, maybe | 15 |
| Big yard area | 13 |
| Big writing assignment | 22 |
| Big wrigglers allied to fight off robins? | 41 |
| Big wrestler | 12 |
| Big World Cup power: Abbr. | 26 |
| Big work | 8 |
| Big words in an atlas | 21 |
| Big words | 9 |
| Big word ref. | 13 |
| Big word on a craps table | 25 |
| Big word on a buck | 18 |
| Big word in German ads | 22 |
| Big word in comics | 18 |
| Big word in advertising | 23 |
| Big wool source | 15 |
| Big women | 9 |
| Big Woman on Campus | 19 |
| Big wins | 8 |
| Big winnings, in slang | 22 |
| Big winnings | 12 |
| Big winner's boast | 22 |
| Big winner of 1967 | 18 |
| Big winner in 1965 | 18 |
| Big winner in 1954 | 18 |
| Big winner in 1937 (with "The") | 41 |
| Big winner at the casino | 24 |
| Big winner | 10 |