| Ancient ruler of the universe | 29 |
| Ancient rulers | 14 |
| Ancient sacred chest | 20 |
| Ancient sailor, in a rime | 25 |
| Ancient salutation | 18 |
| Ancient Samos' region | 25 |
| Ancient satirist who wrote "A True Story" | 51 |
| Ancient Scandinavian | 20 |
| Ancient Scandinavian poems | 26 |
| Ancient Scandinavian poet | 25 |
| Ancient Scandinavian poets | 26 |
| Ancient Scandinavians | 21 |
| Ancient school man? | 19 |
| Ancient scientific quest | 24 |
| Ancient Scientology dictator selling papers on the street? | 58 |
| Ancient Scot | 12 |
| Ancient Scots | 13 |
| Ancient scribe's work surface | 33 |
| Ancient scroll materials | 24 |
| Ancient scrolls | 15 |
| Ancient seaport of Phoenicia | 28 |
| Ancient seaport on the Mediterranean | 36 |
| Ancient seat of Irish kings | 27 |
| Ancient seat of learning | 24 |
| Ancient sect | 12 |
| Ancient seer | 12 |
| Ancient seeress | 15 |
| Ancient seers | 13 |
| Ancient Semite | 14 |
| Ancient Semites | 15 |
| Ancient Semitic deity | 21 |
| Ancient Semitic fertility god | 29 |
| Ancient Semitic fertility goddess | 33 |
| Ancient Semitic god | 19 |
| Ancient Semitic idol | 20 |
| Ancient Semitic people | 22 |
| Ancient Semitic tongue | 22 |
| Ancient septet | 14 |
| Ancient serf | 12 |
| Ancient serfs | 13 |
| Ancient setting of Luxor Temple | 31 |
| Ancient sewer | 13 |
| Ancient sheltered promenade | 27 |
| Ancient shield | 14 |
| Ancient ship | 12 |
| Ancient shrine | 14 |
| Ancient shrines | 15 |
| Ancient siege device | 20 |
| Ancient siege site | 18 |
| Ancient siege weapon | 20 |
| Ancient sinful city | 19 |
| Ancient site of Olympia | 23 |
| Ancient site of Susa | 20 |
| Ancient slave | 13 |
| Ancient social networking suffix | 32 |
| Ancient soothsayer | 18 |
| Ancient sorcerer | 16 |
| Ancient sorcerers | 17 |
| Ancient source of counsel | 25 |
| Ancient South American | 22 |
| Ancient South American empire | 29 |
| Ancient South Americans | 23 |
| Ancient souvenir | 16 |
| Ancient Spanish historian Saint __ of Seville | 45 |
| Ancient Spanish kingdom | 23 |
| Ancient Spanish town | 20 |
| Ancient Spartan king | 20 |
| Ancient Spartan magistrate | 26 |
| Ancient Spartan magistrates | 27 |
| Ancient spell caster | 20 |
| Ancient square | 14 |
| Ancient squares | 15 |
| Ancient steppe warrior | 22 |
| Ancient stone | 13 |
| Ancient stone implement | 23 |
| Ancient stone marker | 20 |
| Ancient stone once thought to be man-made but now believed to have been produced by glaciation | 94 |
| Ancient stone slab | 18 |
| Ancient stone thrower | 21 |
| Ancient stone tomb | 18 |
| Ancient storage jar | 19 |
| Ancient stories | 15 |
| Ancient storyteller | 19 |
| Ancient strategy game played with stones | 40 |
| Ancient string instrument | 25 |
| Ancient stringed instrument | 27 |
| Ancient stringed instrument you shouldn't trust? | 52 |
| Ancient stringed instruments | 28 |
| Ancient strings | 15 |
| Ancient strong box | 18 |
| Ancient strongbox | 17 |
| Ancient strongboxes | 19 |
| Ancient Sudanese kingdom | 24 |
| Ancient suicide helper | 22 |
| Ancient Sumerian city | 21 |
| Ancient sun disk | 16 |
| Ancient sun-god worshiper | 25 |
| Ancient superintendent | 22 |
| Ancient superstition | 20 |
| Ancient symbol | 14 |