| Destiny's Child singer | 26 |
| Destiny's Child soloist | 27 |
| Destiny's Child was one | 27 |
| Destiny's Child, e.g. | 25 |
| Destiny's Child, for one | 28 |
| Destitute of water: Abbr. | 25 |
| Destitute's relief | 22 |
| Destitution, metaphorically | 27 |
| Destroy a large part of | 23 |
| Destroy a recording, in a way | 29 |
| Destroy a Soho structure | 24 |
| Destroy documents, in a way | 27 |
| Destroy evidence, in a way | 26 |
| Destroy in an accident | 22 |
| Destroy papers in a way | 23 |
| Destroy the interior of | 23 |
| Destroy utterly, as a car | 25 |
| Destroy, as a contract | 22 |
| Destroy, as a hotel room | 24 |
| Destroy, as a paper trail | 25 |
| Destroy, as secret papers | 25 |
| Destroy, as unsold paperbacks | 29 |
| Destroy, in another way | 23 |
| Destroy, in Derbyshire | 22 |
| Destroyed beyond repair | 23 |
| Destroyed evidence, in a way | 28 |
| Destroyed Lamb of God jam? | 26 |
| Destroyed little by little | 26 |
| Destroyed, as a letter | 22 |
| Destroyed, as in hopes | 22 |
| Destroyed, as the dragon | 24 |
| Destroyer destroyer, perhaps | 28 |
| Destroyer in 2000 headlines | 27 |
| Destroyer in A.D. LXXIX | 23 |
| Destroyer installation | 22 |
| Destroyer of an ocean inlet? | 28 |
| Destroyer of Saint Pierre | 25 |
| Destroyer of sandcastles | 24 |
| Destroyer of small castles | 26 |
| Destroyer of some castles | 25 |
| Destroyer's apparatus | 25 |
| Destroyer's cousin | 22 |
| Destroyer's depth charge | 28 |
| Destroyer's destroyer | 25 |
| Destroyer's gun platform | 28 |
| Destroyer, in Navy slang | 24 |
| Destroyer, in U.S. Navy slang | 29 |
| Destroyers of les forêts? | 28 |
| Destroyers of many castles | 26 |
| Destroyers, in Navy lingo | 25 |
| Destroyers, in Navy parlance | 28 |
| Destroyers, so to speak | 23 |
| Destroying bit by bit | 22 |
| Destroying angel, for example | 29 |
| Destroys by disintegration | 26 |
| Destroys files, in a way | 24 |
| Destroys sensitive material | 27 |
| Destroys with a ray gun | 23 |
| Destroys, as a hotel room | 25 |
| Destroys, as documents | 22 |
| Destroys, as illusions | 22 |
| Destruction of Isengard vets | 28 |
| Destructive 1966 hurricane | 26 |
| Destructive 1995 hurricane | 26 |
| Destructive 1998 hurricane | 26 |
| Destructive 2004 hurricane | 26 |
| Destructive 2005 hurricane | 26 |
| Destructive 2005 newsmaker | 26 |
| Destructive 2008 hurricane | 26 |
| Destructive computer program | 28 |
| Destructive computer virus | 26 |
| Destructive freshwater fish | 27 |
| Destructive Hindu god (var.) | 28 |
| Destructive hurricane of 2002 | 29 |
| Destructive hurricane of 2005 | 29 |
| Destructive hurricane of 2011 | 29 |
| Destructive kind of rain | 24 |
| Destructive operatives | 22 |
| Destructive peak in Sicily | 26 |
| Destructive precipitation | 25 |
| Destructive rushes of water | 27 |
| Destructive Sicilian peak | 25 |
| Destructive volcano in Sicily | 29 |
| Destructive windstorms | 22 |
| Destructive winter current | 26 |
| Destructively out of control | 28 |
| Det. Joe Friday's show | 26 |
| Det. Sipowicz's employer | 28 |
| Det. Sipowicz's org. | 24 |
| Det. Tiger or N.Y. Yankee | 25 |
| Detach from a dependency | 24 |
| Detach from dependence | 22 |
| Detach, as a book page | 22 |
| Detach, as a campaign button | 28 |
| Detach, as a clothespin | 23 |
| Detach, as a fence gate | 23 |
| Detach, as a lapel mike | 23 |
| Detach, as from a habit | 23 |
| Detach, in a certain way | 24 |
| Detach, with "off" | 28 |