| An electrically charged atom | 28 |
| An electrode | 12 |
| An element | 10 |
| An element in our atmosphere | 28 |
| An element, in Ecuador | 22 |
| An element, to the ancients | 27 |
| An elephant has a big one | 25 |
| An elephant has a long one | 26 |
| An ellipse has two | 18 |
| An ellipse has two of them | 26 |
| An elm is a good one | 20 |
| An embarrassing problem to face? | 32 |
| An embroidery stitch | 20 |
| An emcee may ask a crowd to raise it | 36 |
| An eminent King | 15 |
| An emirate | 10 |
| An Emmy winner for "Love Among the Ruins": 1975 | 57 |
| An emollient | 12 |
| An emoticon's eyes | 22 |
| An emotion | 10 |
| An emperor and a pianist | 24 |
| An emperor and a Wolfe | 22 |
| An employee may accept a package for one | 40 |
| An empty bottle is full of it | 29 |
| An EMT skill | 12 |
| An encouraging word | 19 |
| An encumbrance against property | 31 |
| An end for depend | 17 |
| An end in _____ | 15 |
| An End of London | 16 |
| An end to alcohol? | 18 |
| An end to honor? | 16 |
| An end to motion | 16 |
| An end to peace | 15 |
| An end to peace? | 16 |
| An end to prayers | 17 |
| An end to Satan? | 16 |
| An end to sex? | 14 |
| An end to television | 20 |
| An ending | 9 |
| An ending for "play" | 30 |
| An ending to beat | 17 |
| An ending to grace | 18 |
| An endocrine gland | 18 |
| An energy source | 16 |
| An Eng. king | 12 |
| An English channel, with "The" | 40 |
| An English cider apple | 22 |
| An English horn is a fifth lower than it | 40 |
| An English horn is lower than it | 32 |
| An English poet and a U.S. actor | 32 |
| An English royal house | 22 |
| An Englishman | 13 |
| An ens. may be in it | 20 |
| An enthusiast of | 16 |
| An entree | 9 |
| An entrepreneur may bankroll one | 32 |
| An envisioned America, moneywise | 32 |
| An enzyme | 9 |
| An EPA concern | 14 |
| An epic clout? | 14 |
| An epicure has a refined one | 28 |
| An epithet of Juno | 18 |
| An equal | 8 |
| An equal number of | 18 |
| An equal share, say | 19 |
| An equilateral parallelogram | 28 |
| An equine color | 15 |
| An ergosphere surrounds it | 26 |
| An Eskimo roll might right one | 30 |
| An essay may be on one | 22 |
| An essayist's pen name | 26 |
| An essayist's work is in it | 31 |
| An essential amino acid | 23 |
| An essential element | 20 |
| An essential ingredient | 23 |
| An essential vitamin | 20 |
| An established custom | 21 |
| An ester used in ointments | 26 |
| An estuary of the Amazon | 24 |
| An eternity | 11 |
| An eternity, seemingly | 22 |
| An Evangelist | 13 |
| An evangelist's first name | 30 |
| An evasive dance before Thanksgiving? | 37 |
| An Eve | 6 |
| An evening in Florence | 22 |
| An evening of TV viewing, e.g. | 30 |
| An evening party | 16 |
| An event to honor the best hospital patient? | 44 |
| An event won by Jesse Owen | 26 |
| An evergreeen | 13 |
| An evergreen | 12 |
| An evil soul's sin? (Anagram) | 33 |
| An evil spirit | 14 |
| An ex of Artie | 14 |
| An ex of Artie and Frank | 24 |
| An ex of Artie, Mickey and Frank | 32 |
| An ex of Ava | 12 |
| An ex of Burt | 13 |