| Middle Ages instrument | 22 |
| Middle Ages landmark | 20 |
| Middle Ages literary figure | 27 |
| Middle Ages manager | 19 |
| Middle Ages pseudoscience | 25 |
| Middle Ages quaff | 17 |
| Middle Ages rival of Venice | 27 |
| Middle Ages scientist | 21 |
| Middle Ages shield | 18 |
| Middle Ages stoneworker | 23 |
| Middle Ages weapons | 19 |
| Middle alternative? | 19 |
| Middle America symbol of 2008 politics | 38 |
| Middle America, to some snooty intercoastal travelers | 53 |
| Middle amts. | 12 |
| Middle and Dark | 15 |
| Middle and Far | 14 |
| Middle and Stone | 16 |
| Middle bit of a Venn diagram | 28 |
| Middle Brady Bunch girl | 23 |
| Middle Brady girl | 17 |
| Middle brother in a 2000s pop trio | 34 |
| Middle C, e.g. | 14 |
| Middle class resident, in the Middle Ages | 41 |
| Middle Corleone brother | 23 |
| Middle course | 13 |
| Middle daughter on "Downton Abbey" | 44 |
| Middle distance runner Steve who won Olympic gold in 1980 | 57 |
| Middle ear bone | 15 |
| Middle ear membrane | 19 |
| Middle ear part | 15 |
| Middle ear part? | 16 |
| Middle ear? | 11 |
| Middle ears | 11 |
| Middle ears? | 12 |
| Middle Earth being | 18 |
| Middle Earth beings | 19 |
| Middle Earth creatures | 22 |
| Middle Earth inhabitant | 23 |
| Middle Earth marauder | 21 |
| Middle Earth meanie | 19 |
| Middle Earth menace | 19 |
| Middle Earth resident | 21 |
| Middle Earth thug | 17 |
| Middle earth? | 13 |
| Middle East airline | 19 |
| Middle East asset | 17 |
| Middle East big shots | 21 |
| Middle East bigwig | 18 |
| Middle East bigwigs | 19 |
| Middle East bread | 17 |
| Middle East canal | 17 |
| Middle East capital | 19 |
| Middle East carrier with a blue and white flag | 46 |
| Middle East chieftain | 21 |
| Middle East chieftain (Var.) | 28 |
| Middle East chieftains | 22 |
| Middle East country | 19 |
| Middle East currency | 20 |
| Middle East denizen | 19 |
| Middle East desert region | 25 |
| Middle East diplomat | 20 |
| Middle East emirate | 19 |
| Middle East energy crisis? | 26 |
| Middle East fiddle | 18 |
| Middle East flier | 17 |
| Middle East form of government | 30 |
| Middle East garment | 19 |
| Middle East gp. | 15 |
| Middle East gp. since 1964 | 26 |
| Middle East group with observer status in the UN | 48 |
| Middle East gulf | 16 |
| Middle East honchos | 19 |
| Middle East hot spot | 20 |
| Middle East import frequently put under sanctions | 49 |
| Middle East initials: 1958-71 | 29 |
| Middle East inn | 15 |
| Middle East land | 16 |
| Middle East language | 20 |
| Middle East language group | 26 |
| Middle East leader | 18 |
| Middle East leader raised in Milwaukee | 38 |
| Middle East leaders | 19 |
| Middle East liquor | 18 |
| Middle East marketplace | 23 |
| Middle East meas. | 17 |
| Middle East moola | 17 |
| Middle East name | 16 |
| Middle East nation | 18 |
| Middle East native | 18 |
| Middle East notable | 19 |
| Middle East org. | 16 |
| Middle East org., formerly | 26 |
| Middle East peninsula | 21 |
| Middle East people: Comb. form | 30 |
| Middle East person | 18 |
| Middle East poobah | 18 |
| Middle East Pooh Bah | 20 |
| Middle East potentate | 21 |
| Middle East prince | 18 |