| American statesman | 18 |
| American statesman Root | 23 |
| American stinger | 16 |
| American suffragist | 19 |
| American suffragist and reformer | 32 |
| American suffragist honored with a 1995 stamp | 45 |
| American swimmer whose relay team set a world record in the women's 4×100 freestyle at the 1924 Olympics | 112 |
| American symbol | 15 |
| American symbols that stand out? | 32 |
| American taxpayer's ID | 26 |
| American tennis icon Arthur | 27 |
| American tennis star | 20 |
| American territory | 18 |
| American territory in the Pacific | 33 |
| American theater for six years as of March 20, 2009 | 51 |
| American Theatre Wing award | 27 |
| American thrush | 15 |
| American toy introduced in 1945 | 31 |
| American trailing plant | 23 |
| American travel expense | 23 |
| American trees | 14 |
| American trial lawyer | 21 |
| American tribe | 14 |
| American tribe that lent its name to a state | 44 |
| American trumpet player Armstrong | 33 |
| American turtle | 15 |
| American uncle | 14 |
| American University locale | 26 |
| American university where Desmond Tutu taught theology | 54 |
| American vintner | 16 |
| American violet [right hand] | 28 |
| American violinist | 18 |
| American visiting the Eiffel Tower, e.g. | 40 |
| American vodka brand | 20 |
| American voters before 1920 | 27 |
| American vulture | 16 |
| American wapitis | 16 |
| American warbler | 16 |
| American watcher, for short | 27 |
| American watercolorist | 22 |
| American way? | 13 |
| American web site info | 22 |
| American whiskies | 17 |
| American wildcat | 16 |
| American wildcats | 17 |
| American with a British accent | 30 |
| American with a crown | 21 |
| American with Japanese immigrant parents | 40 |
| American with Japanese parents | 30 |
| American worker | 15 |
| American worker? | 16 |
| American writer | 15 |
| American writer Bret | 20 |
| American writer Plath | 21 |
| American __ | 11 |
| American __ (veterans' group) | 33 |
| American __, Massachusetts state tree | 37 |
| American __, North Dakota state tree | 36 |
| American __: Pacific territory | 30 |
| American ___ | 12 |
| American ___ (century plant) | 28 |
| American ___ (Massachusetts state tree) | 39 |
| American ___ (North Dakota's state tree) | 44 |
| American ___ (noted dictionary name) | 36 |
| American ___ (Pacific Ocean territory) | 38 |
| American ___ (Southwest plant) | 30 |
| American ___ (state tree of Massachusetts) | 42 |
| American ___ (U.S. territory) | 29 |
| American ___ (univ. course) | 27 |
| American ___ (veterans' group) | 34 |
| American ___, state tree of Del. | 32 |
| American ______ | 15 |
| American _______ | 16 |
| American ________ | 17 |
| American's main course | 26 |
| American's Olympics cheer | 29 |
| American's omega | 20 |
| American's Swiss bank account, e.g. | 39 |
| American's uncle | 20 |
| American, abroad | 16 |
| American, e.g. | 14 |
| American, for one | 17 |
| American, in England | 20 |
| American, in Europe: Slang | 26 |
| American, overseas | 18 |
| American, Swiss, etc. | 21 |
| American, to a Brit | 19 |
| American, to a British monarch | 30 |
| American, to Brits | 18 |
| American-born Canuck insulin inventor | 37 |
| American-born Impressionist | 27 |
| American-born Japanese | 22 |
| American-born Jordanian queen | 29 |
| American-born painter | 21 |
| American-born princess | 22 |
| American-born queen | 19 |
| American-born queen of Jordan | 29 |
| American-Canadian for ghetto blaster | 36 |
| American-Chinese eatery? | 24 |
| American-plan items | 19 |