| First airline to operate a transpolar route | 43 |
| First airing | 12 |
| First aide, for short? | 22 |
| First aid technique (abbr.) | 27 |
| First aid staple | 16 |
| First aid provider, for short | 29 |
| First aid provider, briefly | 27 |
| First aid plant | 15 |
| First aid or mess | 17 |
| First aid ointment | 18 |
| First aid kit staple | 20 |
| First aid kit item | 18 |
| First aid item | 14 |
| First aid for sprains | 21 |
| First aid for a sprain | 22 |
| First aid equipment | 19 |
| First aid case | 14 |
| First aid boxes | 15 |
| First aid box | 13 |
| First aid balm | 14 |
| First aid administrant on a battlefield | 39 |
| First age in geologic history | 29 |
| First African-born Literature Nobelist | 38 |
| First African-American US Open champ | 36 |
| First African-American to win a Gold Glove in both leagues | 58 |
| First African-American to play at the Masters | 45 |
| First African-American selected for a U.S. Davis Cup team | 57 |
| First African-American secretary of state | 41 |
| First African-American Republican National Committee chairman | 61 |
| First African-American on a US stamp | 36 |
| First African-American major-league coach Buck | 46 |
| First African-American major-league coach | 41 |
| First African-American major-league catcher | 43 |
| First African-American golfer with 12 P.G.A. Tour wins | 54 |
| First African-American golfer to play in the Masters | 52 |
| First AFL team to beat an NFL team | 34 |
| First AFL president, Samuel | 27 |
| First actress to win an Oscar in a foreign-language film | 56 |
| First actress to play Yente in Broadway's "Fiddler on the Roof" | 77 |
| First actor to turn down an Academy Award | 41 |
| First actor to play Loman | 25 |
| First action sequence of "Saving Private Ryan" | 56 |
| First action figure | 19 |
| First act of the ballet "Jewels," by George | 53 |
| First act in a revue | 20 |
| First act | 9 |
| First acrylic fiber | 19 |
| First Across word in the world's first crossword | 52 |
| First abode | 11 |
| First A.F.L.-C.I.O. president | 29 |
| First A-bomb test | 17 |
| First 45 maker, briefly | 23 |
| First 3 of 26 | 13 |
| First 10 amendments | 19 |
| First 007 flick (abbr.) | 23 |
| First 007 flick | 15 |
| First 007 film | 14 |
| First ... | 9 |
| First (Abbr.) | 13 |
| First "Today" host Dave | 33 |
| First "Sunday Morning" host | 37 |
| First "O" of O-O-O | 28 |
| First "Mission: Impossible" TV production company | 59 |
| First "Match Game" announcer | 38 |
| First "Idol" winner Clarkson | 38 |
| First "Great" pope | 28 |
| First "Family Feud" host | 34 |
| First "Commander of the Faithful" | 43 |
| First "Come on down!" announcer | 41 |
| First "Bond girl" | 27 |
| First "Blue's Clues" host | 39 |
| First "Bachelorette" Trista | 37 |
| First "American Idol" winner Clarkson | 47 |
| First "America's Funniest Home Videos" host | 57 |
| First ''Time'' publisher | 40 |
| First ''L'' of L.L. Bean | 40 |
| First ''A'' of A.A. Milne | 41 |
| First #1 hit for the Ink Spots | 30 |
| First #1 hit for the Commodores | 31 |
| First #1 hit by the Beach Boys | 30 |
| First #1 Billboard hit by an Australian artist (1972) | 53 |
| First second or third | 22 |
| First | 5 |
| Firrier? | 8 |
| Firpo of the ring | 17 |
| Firpo of boxing | 15 |
| Firpo | 5 |
| Firn | 4 |
| Firms: Abbr. | 12 |
| Firms, for short | 16 |
| Firms, as abs | 13 |
| Firms up, as muscles | 20 |
| Firms up, as concrete | 21 |
| Firms up | 8 |
| Firms muscles | 13 |
| Firms (up) | 10 |
| Firms (abbr.) | 13 |
| Firms | 5 |
| Firmness of spirit | 18 |
| Firmness of purpose | 19 |