| American designer of Russian descent | 36 |
| American dessert | 16 |
| American device | 15 |
| American Dialect Society's word of the year, 2009 | 53 |
| American diarist Anais | 22 |
| American diner favorite | 23 |
| American doctor and author | 26 |
| American dogwood | 16 |
| American dogwood used in basketry | 33 |
| American dogwood: red ___ | 25 |
| American dogwoods | 17 |
| American dramatist | 18 |
| American edition of elle? | 25 |
| American editor | 15 |
| American education reformer | 27 |
| American educator | 17 |
| American educator reformer Horace | 33 |
| American electrical engineer and inventor | 41 |
| American elk | 12 |
| American emblem | 15 |
| American employee | 17 |
| American engineer and inventor | 30 |
| American enticements | 20 |
| American equivalent of Britain's MI6 | 40 |
| American equivalent of kPa | 26 |
| American espionage org. | 23 |
| American essayist | 17 |
| American everyman | 17 |
| American Expeditionary Forces commander | 39 |
| American explorer and filmmaker Johnson | 39 |
| American Express alternative | 28 |
| American Express card | 21 |
| American Express card introduced in 1987 | 40 |
| American Express card with a smart chip | 39 |
| American Express credit card | 28 |
| American Express or Kia product | 31 |
| American Express rival | 22 |
| American Express's first credit card | 40 |
| American fabulist | 17 |
| American falcon | 15 |
| American Falls locale | 21 |
| American fantasy writer David | 29 |
| American farm machinery industrialist | 37 |
| American fashion designer | 25 |
| American feline, for one | 24 |
| American felines | 16 |
| American feminist | 17 |
| American fig. | 13 |
| American film director | 22 |
| American Film Institute's "greatest male star of all time" | 72 |
| American finch | 14 |
| American fish | 13 |
| American flag | 13 |
| American flag color | 19 |
| American flag feature | 21 |
| American flag-maker Ross | 24 |
| American flags that are worn out? | 33 |
| American flier with scarlet patches | 35 |
| American Flyer maker | 20 |
| American Flyer rival | 20 |
| American folk artist | 20 |
| American folk ballad | 20 |
| American folk instrument | 24 |
| American folk-singer Guthrie | 28 |
| American food staple | 20 |
| American foreign policy re business interests | 45 |
| American founder of the scouts | 30 |
| American from Fukuoka, say | 26 |
| American frontiersman | 21 |
| American Fur Company founder | 28 |
| American fur trader | 19 |
| American game animal | 20 |
| American Girl collection | 24 |
| American Girl doll maker | 24 |
| American Girl product | 21 |
| American Girl purchase | 22 |
| American Gladiators final round | 31 |
| American goldfinch | 18 |
| American Graffiti drive-in | 29 |
| American Greetings "mailing" | 38 |
| American Greetings icon | 23 |
| American Greetings logo | 23 |
| American guess: Abbr. | 21 |
| American H.Q. abroad | 20 |
| American hardwood | 17 |
| American Head Charge "Just ___ Know" | 46 |
| American Heart Mo. | 18 |
| American Heart Mo. (appropriately) | 34 |
| American historian | 18 |
| American historical event, upon landing? | 40 |
| American Hockey League affiliate of the Wild | 44 |
| American Hockey League team from Houston | 40 |
| American hockey Olympians, collectively | 39 |
| American hog | 12 |
| American holly | 14 |
| American Horse of the Year, e.g. | 32 |
| American hub | 12 |
| American humorist | 17 |
| American humorist George | 24 |
| American humorist: 1850-96 | 26 |