| First eviction site | 19 |
| First event in a series | 23 |
| First European to reach the Pacific | 35 |
| First European to reach New Zealand | 35 |
| First European to reach India by sea | 36 |
| First European to land in North America | 39 |
| First European to enter New York Bay | 36 |
| First European to discover Tahiti | 33 |
| First European to discover Alaska | 33 |
| First European to cross the Mississippi | 39 |
| First European to cross America | 31 |
| First European on Prince Edward Island | 38 |
| First European nation to win the World Cup | 42 |
| First European explorer to see New Zealand | 42 |
| First estate | 12 |
| First episodes | 14 |
| First episode of many a series | 30 |
| First episode in a TV series | 28 |
| First episode | 13 |
| First entry in a crossword to a constructor | 43 |
| First entry in ''Who's Who in the Bible'' | 61 |
| First English printer | 21 |
| First English king | 18 |
| First English globe-girdler | 27 |
| First English commander to see the Pacific | 42 |
| First English colony in America | 31 |
| First English child born in America | 35 |
| First emperor of Brazil | 23 |
| First emperor of Austria | 24 |
| First Emmy-winning song | 23 |
| First Emmy song hit: 1955 | 25 |
| First elements | 14 |
| First electronic stock market | 29 |
| First electronic computer | 25 |
| First elected member at Cooperstown | 35 |
| First elected governor of Alaska | 32 |
| First elected Congresswoman Jeannette | 37 |
| First Egyptian king | 19 |
| First efforts at compromise | 27 |
| First editor of The Atlantic Monthly | 36 |
| First editor of "The Overland Monthly" | 48 |
| First edition, usually | 22 |
| First ed. | 9 |
| First earth orbiter | 19 |
| First Earl of Leicester | 23 |
| First Earl of Chatham | 21 |
| First Earl of Beaconsfield | 26 |
| First Earl of Avon | 18 |
| First dynasty of Polish rulers | 30 |
| First Dynasty in Chinese history | 32 |
| First duke of Normandy | 22 |
| First drug approved to treat AIDS | 33 |
| First drink of hot coffee, e.g. | 31 |
| First drink ever ordered by James Bond | 38 |
| First Dreamliner buyer | 22 |
| First drawing class, perhaps | 28 |
| First drawing | 13 |
| First drawer of the Democratic donkey | 37 |
| First draft | 11 |
| First Dracula of film | 21 |
| First Dr. Kildare | 17 |
| First down? | 11 |
| First double-digit number | 25 |
| First double, and first female, Nobelist | 40 |
| First donor? | 12 |
| First Dominican-born Major League Baseball manager | 50 |
| First Dominican manager in the major leagues | 44 |
| First Dominican manager in MLB history | 38 |
| First Dominican major-league manager | 36 |
| First domed ballpark | 20 |
| First dog walker, maybe | 23 |
| First dog to orbit Earth | 24 |
| First Dog of the 1940s | 22 |
| First dog in space | 18 |
| First Dodge with front-wheel drive | 34 |
| First divorced U.S. president | 29 |
| First division of an act | 24 |
| First distiller to sell whiskey by the bottle | 45 |
| First discovered asteroid | 25 |
| First director of the U.S. Peace Corps | 38 |
| First dinner course | 19 |
| First dime novel: Var. | 22 |
| First digs? | 11 |
| First digital computer | 22 |
| First digit of current year | 27 |
| First digit in an Alaskan zip code | 34 |
| First digit in a Hawaiian zip code | 34 |
| First digit in a California zip code | 36 |
| First digit a toddler is taught, often | 38 |
| First designated spot at a swim meet, perhaps | 45 |
| First degs. | 11 |
| First degrees (abbr.) | 21 |
| First degrees | 13 |
| First defenseman to lead N.H.L. in scoring | 42 |
| First deadly sin | 16 |
| First day of the rest of your life | 34 |
| First day of the month, in ancient Rome | 39 |
| First day of summer or winter | 29 |
| First day of spring, to Vietnamese | 34 |
| First day of most PGA tourneys | 30 |