| First film in CinemaScope, 1953 | 31 |
| First film critic to win a Pulitzer | 35 |
| First filly to win the Kentucky Derby | 37 |
| First fill-in on some IRS forms | 31 |
| First fill-in on a form | 23 |
| First fighter to KO Liston | 26 |
| First fifth of a Shakespeare play | 33 |
| First FIFA World Cup winner | 27 |
| First Fiesta Bowl winner: Abbr. | 31 |
| First few chips, usually | 24 |
| First few bars | 14 |
| First female U.S. attorney general | 34 |
| First female to swim the Channel | 32 |
| First female Supreme? | 21 |
| First female Supreme Court Justice | 34 |
| First female Speaker of the House | 33 |
| First female speaker of Canada's parliament | 47 |
| First female Sorbonne professor | 31 |
| First female solo artist in the Country Music Hall of Fame | 58 |
| First female skater to land a triple/triple jump combination in competition | 75 |
| First female singer to have three different singles in Billboard's Top 10 at one time | 89 |
| First female Secretary of the Interior (2001-06) | 48 |
| First female professor at the University of Paris | 49 |
| First female Nobelist | 21 |
| First female member of the British Parliament | 45 |
| First female member of Parliament | 33 |
| First female Mayor of a Canadian city | 37 |
| First female Indy 500 Rookie of the Year ___ St. James | 54 |
| First female in Parliament | 26 |
| First female director of U.S. Mint: 1933 | 40 |
| First female director of U.S. Mint | 34 |
| First female dean of Harvard Law School | 39 |
| First female chancellor of Germany | 34 |
| First female candidate to win the Ames Straw Poll | 49 |
| First female attorney general | 29 |
| First female athlete to host "SNL" | 44 |
| First female athlete on the front of a Wheaties box | 51 |
| First female astronaut | 22 |
| First female appointed to our Supreme Court | 43 |
| First female | 12 |
| First felony victim | 19 |
| First felony conviction, in some states | 39 |
| First felon | 11 |
| First fellow | 12 |
| First FBI director | 18 |
| First father | 12 |
| First fast-food fancier | 23 |
| First farmers to use yoked teams? | 33 |
| First farmer | 12 |
| First Family: 1977-81 | 21 |
| First Family: 1881–85 | 28 |
| First Family, 1909-1913 | 23 |
| First family's son | 22 |
| First family's residence? | 29 |
| First family's residence | 28 |
| First family's home? | 24 |
| First family's home | 23 |
| First family's grandson | 27 |
| First family's garden site? | 31 |
| First family's address? | 27 |
| First family when the Titanic sank | 34 |
| First family when D.C.'s earliest cherry trees were planted | 63 |
| First Family uncle | 18 |
| First family starting in 2009 | 29 |
| First Family of Va. | 19 |
| First family of the early 20th century | 38 |
| First Family of the 1980s | 25 |
| First family of the 1970s | 25 |
| First family of the 1910s | 25 |
| First family of the 1840s | 25 |
| First family of Mexico: 1851-53 | 31 |
| First Family of Hawaii: 1900–03 | 38 |
| First family of Germany, 1969-74 | 32 |
| First family of Ferrara | 23 |
| First family of Egypt, once | 27 |
| First Family of early Ferrara | 29 |
| First family of Chicago | 23 |
| First Family of Alaska in the 60's | 38 |
| First Family of 2010 | 20 |
| First family of 1975 | 20 |
| First family of 1910 | 20 |
| First family of 1850 | 20 |
| First family of 1842 | 20 |
| First family member? | 20 |
| First family member | 19 |
| First family home | 17 |
| First family greeting | 21 |
| First family grandson | 21 |
| First family father | 19 |
| First family before the Wilsons | 31 |
| First Family at Albany | 22 |
| First family as of 2009 | 23 |
| First family | 12 |
| First Families of Virginia surname | 34 |
| First fall setting | 18 |
| First extra inning | 18 |
| First extra baseball inning | 27 |
| First explorer to sail directly from Europe to India | 52 |
| First experience | 16 |
| First excuse | 12 |