| Big S.A. birds | 14 |
| Big safari men | 14 |
| Big sale | 8 |
| Big salmon order for a security firm? | 37 |
| Big sandwich | 12 |
| Big sandwich name | 17 |
| Big sandwich, for short | 23 |
| Big sandwiches | 14 |
| Big Sauvignon swig? | 19 |
| Big scale manufacturer | 22 |
| Big scallion | 12 |
| Big scary white dude | 20 |
| Big schlep | 10 |
| Big Schott | 10 |
| Big scissors | 12 |
| Big score on the floor | 22 |
| Big score, maybe | 16 |
| Big scorer alongside Yao, to fans | 33 |
| Big Scouts meeting | 18 |
| Big scrap | 9 |
| Big screen | 10 |
| Big screen film format | 22 |
| Big screen format | 17 |
| Big screen letters | 18 |
| Big screen locale | 17 |
| Big screen name | 15 |
| Big screen pig | 14 |
| Big screen theatre | 18 |
| Big scuffle | 11 |
| Big season at Toys "R" Us | 35 |
| Big season at Toys"R"Us | 33 |
| Big Seattle philanthropist | 26 |
| Big section in a dictionary | 27 |
| Big section of a dictionary | 27 |
| Big section of Bartlett's: Abbr. | 36 |
| Big section of the dictionary | 29 |
| Big sections of dictionaries | 28 |
| Big security device? | 20 |
| Big selection of meat | 21 |
| Big seller for Chris Rock | 25 |
| Big seller in bear markets | 26 |
| Big seller in bear markets? | 27 |
| Big seller of acetaminophen | 27 |
| Big seller of smoothies | 23 |
| Big seller, supposedly | 22 |
| Big series name in auto racing | 30 |
| Big serve | 9 |
| Big server | 10 |
| Big servers | 11 |
| Big serving bowls | 17 |
| Big serving spoon | 17 |
| Big shade trees | 15 |
| Big shakeup? | 12 |
| Big share | 9 |
| Big shareholder? | 16 |
| Big sheet | 9 |
| Big sheet of ice | 16 |
| Big shells | 10 |
| Big shindig | 11 |
| Big shiner | 10 |
| Big ship | 8 |
| Big shirt maker | 15 |
| Big shock | 9 |
| Big shock wave producer, briefly | 32 |
| Big shock? | 10 |
| Big shoe request | 16 |
| Big shoe size | 13 |
| Big shoe spec | 13 |
| Big shoe specification in Libya? | 32 |
| Big shoes to fill | 17 |
| Big shooter | 11 |
| Big shopping bag | 16 |
| Big shortages | 13 |
| Big shot | 8 |
| Big shot after making a big shot, maybe: Abbr. | 46 |
| Big shot at a bar? | 18 |
| Big shot at the bar? | 20 |
| Big shot at Wimbledon | 21 |
| Big shot in charge of locksmiths? | 33 |
| Big shot in hockey | 18 |
| Big shot in Iberia | 18 |
| Big shot in ice hockey | 22 |
| Big shot in the bar? | 20 |
| Big shot in the flexible straw industry? | 40 |
| Big shot in the Mideast | 23 |
| Big shot in the office | 22 |
| Big shot in the salad factory? | 30 |
| Big shot in the sky | 19 |
| Big shot of industry | 20 |
| Big shot of Venice | 18 |
| Big shot on Al Jazeera | 22 |
| Big shot on the board | 21 |
| Big shot overseeing metamorphoses? | 34 |
| Big shot with the bucks | 23 |
| Big shot's big wheels | 25 |
| Big shot's opposite? | 24 |
| Big shot's shot? | 20 |
| Big shot's transportation | 29 |
| Big shot's vehicle | 22 |
| Big shot's wheels | 21 |