| It sees across the border | 25 |
| It sees things | 14 |
| It seldom made Cerf bored | 25 |
| It sells | 8 |
| It sells a lot of build-it-yourself furniture | 45 |
| It sells in advertising, they say | 33 |
| It sells, apparently | 20 |
| It sells, it's said | 23 |
| It sells, reportedly | 20 |
| It sells, they say | 18 |
| It sends checks to A.A.R.P. members | 35 |
| It sends Olympians flying | 25 |
| It sends out lots of streams | 28 |
| It sends people on trips | 24 |
| It sent Dorothy to Oz | 21 |
| It sent Timothy Leary on a trip | 31 |
| It separated from the Czech Republic in 1993 | 44 |
| It separated Martin from Lewis | 30 |
| It separates ''pay'' from ''view'' | 66 |
| It separates actors from audiences | 34 |
| It separates by means | 21 |
| It separates by means? | 22 |
| It separates countries | 22 |
| It separates dollars and cents | 30 |
| It separates hours from minutes | 31 |
| It separates inlaws at the wedding | 34 |
| It separates Kazakhstan and Uzbekistan | 38 |
| It separates McEnroe from Borg | 30 |
| It separates money and everything | 33 |
| It separates seeds | 18 |
| It separates Sicily from the rest of Italy | 42 |
| It separates the Bering Sea from the Pacific | 44 |
| It separates the girls from the boys | 36 |
| It separates the lead singer from the band? | 43 |
| It separates the men from the boys | 34 |
| It separates two breaks | 23 |
| It separates two names | 22 |
| It served the Mid-Atlantic until 1976 | 37 |
| It serves a duel purpose | 24 |
| It serves as a reminder | 23 |
| It serves Jerusalem | 19 |
| It serves many courses: Abbr. | 29 |
| It serves no useful purpose | 27 |
| It serves Stockholm | 19 |
| It serves Tel Aviv | 18 |
| It serves the telly | 19 |
| It set sail from Iolcus | 23 |
| It set sail in 1492 | 19 |
| It sets off a ringtone | 22 |
| It sets off dynamite | 20 |
| It sets off the alarm | 21 |
| It sets standards for attys. | 28 |
| It sets the agenda | 18 |
| It sets the scene | 17 |
| It sets the tone | 16 |
| It sets things apart | 20 |
| It sets things off | 18 |
| It settles indoors | 18 |
| It settles on petals | 20 |
| It settles on sweeps | 20 |
| It settles the score | 20 |
| IT setups | 9 |
| It shares a 45-mile border with Canada | 38 |
| It shares a border with Montana | 31 |
| It shares a border with Switzerland | 35 |
| It shares a flag with Formentera | 32 |
| It shares a key with 8 | 22 |
| It shares a key with the slash | 30 |
| It shares its airport shuttle with National | 43 |
| It shares space with the "!" | 38 |
| It shares the same keys as a G major scale | 42 |
| It shines above Cancun | 22 |
| It shines in España | 22 |
| It shines on Mejico | 19 |
| It shines on the Seine | 22 |
| It ships with Macs | 18 |
| It ships with most Apples | 25 |
| It shoots the breeze | 20 |
| It should be airtight | 21 |
| It should be changed regularly | 30 |
| It should be clean enough to eat off | 36 |
| It should be earned | 19 |
| It should be even | 17 |
| It should be flaky | 18 |
| It should be in the trunk | 25 |
| It should be in time for a concert | 34 |
| It should be low on a diamond | 29 |
| It should be raised in the office | 33 |
| It should be raised on a ship | 29 |
| It should be tightened until it clicks | 38 |
| It should be written in the leftmost column | 43 |
| It should come back to you after a while: Abbr. | 47 |
| It should come first | 20 |
| It should cover Santa | 21 |
| It should end with a reception | 30 |
| It should get nixed | 19 |
| It should go on a head | 22 |
| It should have a head and a good body | 37 |
| It should have no effect | 24 |
| It should help you breathe easier | 33 |