| Big oafs | 8 |
| Big occasion | 12 |
| Big oil cartel (abbr.) | 22 |
| Big oil company | 15 |
| Big oil company, for short | 26 |
| Big oil company, informally | 27 |
| Big oil exporter | 16 |
| Big oil gp. | 11 |
| Big Oil merger of 1998 | 22 |
| Big oil source | 14 |
| Big oil supplier | 16 |
| Big ol' nose | 16 |
| Big ol' pile | 16 |
| Big ol' stumblebum | 22 |
| Big ol' zeros | 17 |
| Big olive oil exporter | 22 |
| Big on | 6 |
| Big on top? | 11 |
| Big one | 7 |
| Big one in baseball | 19 |
| Big one in London | 17 |
| Big one in parliament | 21 |
| Big one on the set, perhaps | 27 |
| Big ones are often fought over | 30 |
| Big ones can be chairs | 22 |
| Big ones can impede progress | 28 |
| Big ones often clash | 20 |
| Big opening? | 12 |
| Big operatic ending | 19 |
| Big or baby, e.g. | 17 |
| Big or bright thing | 19 |
| Big or Franklin | 15 |
| Big or full follower | 20 |
| Big or Gentle | 13 |
| Big or Little | 13 |
| Big or little digit | 19 |
| Big or little dipper | 20 |
| Big or little follower | 22 |
| Big or Little in the sky | 24 |
| Big or Little Poison | 20 |
| Big or Little, in the night sky | 31 |
| Big or top follower | 19 |
| Big Orange of college sports | 28 |
| Big order | 9 |
| Big org. come April | 19 |
| Big ornate cabinet | 18 |
| Big overhead? | 13 |
| Big ox | 6 |
| Big ox, say | 11 |
| Big oxygen producer | 19 |
| Big P&G brand | 17 |
| Big pain | 8 |
| Big pain for an elephant? | 25 |
| Big painting | 12 |
| Big pair | 8 |
| Big palooka | 11 |
| Big palookas | 12 |
| Big pan | 7 |
| Big pane | 8 |
| Big paper, for short | 20 |
| Big paperback publisher | 23 |
| Big Papi | 8 |
| Big Papi's team | 19 |
| Big Papi's team, on scoreboards | 35 |
| Big parade organizer | 20 |
| Big parrot | 10 |
| Big parrots | 11 |
| Big part | 8 |
| Big part of a crocodile | 23 |
| Big part of a dinosaur skeleton | 31 |
| Big part of a grade | 19 |
| Big part of a grade, often | 26 |
| Big part of a hare | 18 |
| Big part of a trucker's budget | 34 |
| Big part of an elephant | 23 |
| Big part of an Obama caricature? | 32 |
| Big part of an order | 20 |
| Big part of California? | 23 |
| Big part of magazine income | 27 |
| Big part of many a family budget | 32 |
| Big part of the dairy business? | 31 |
| Big part of the Sicilian scenery | 32 |
| Big parties | 11 |
| Big party | 9 |
| Big party assessment? | 21 |
| Big party bottles | 17 |
| Big party for jalopy owners? | 28 |
| Big party: Abbr. | 16 |
| Big partygoer? | 14 |
| Big payoff | 10 |
| Big payoff bet | 14 |
| Big payroll service co. | 23 |
| Big PC maker | 12 |
| Big period | 10 |
| Big periods | 11 |
| Big pet food brand | 18 |
| Big petrol seller | 17 |
| Big pharma name, for short | 26 |
| Big Pharma regulating org. | 26 |
| Big Pharma regulator | 20 |