| First pope called "the Great" | 39 |
| First pope | 10 |
| First Polynesian man | 20 |
| First political organization? | 29 |
| First poet to use the terza rima verse form | 43 |
| First poet to read at a presidential inauguration | 49 |
| First player whose HR was reviewed (and upheld) by umpires using instant replay | 79 |
| First player to win the Hart Trophy three times in a row | 56 |
| First player to win tennis's Grand Slam | 43 |
| First player to hit an inside-the-park home run during an All-Star Game, 2007 | 77 |
| First player off the bench | 26 |
| First player listed in "Total Baseball" | 49 |
| First player elected to the Baseball Hall of Fame | 49 |
| First plant cited in the Bible | 30 |
| First planet: Abbr. | 19 |
| First planet, alphabetically | 28 |
| First planet discovered using a telescope | 41 |
| First place? | 12 |
| First place! | 12 |
| First place resident? | 21 |
| First place on a marquee | 24 |
| First place of habitation | 25 |
| First place mentioned in the Beach Boys' "Kokomo" | 63 |
| First place award perhaps | 26 |
| First place . | 13 |
| First place | 11 |
| First pivoting-head razor brand | 31 |
| First pitcher to record 5,000 career strikeouts | 47 |
| First pitcher to have defeated all 30 major-league teams | 56 |
| First pilot to travel faster than the speed of sound | 52 |
| First pilot to exceed Mach 1 | 28 |
| First piece of trial evidence | 29 |
| First piece of evidence presented at trial | 42 |
| First picks | 11 |
| First pick, slangily | 20 |
| First pianist to use a jazz organ | 33 |
| First Physics Nobelist | 22 |
| First philosopher to mention Atlantis | 37 |
| First phases | 12 |
| First phase | 11 |
| First PGA player to shoot his age, with a 67 | 44 |
| First Peruvian city to gain independence from Spain | 51 |
| First person? | 13 |
| First person, to Angela Merkel | 30 |
| First person, in Vienna | 23 |
| First person you see at some fine restaurants | 45 |
| First person with two Nobel Prizes | 34 |
| First person to win a Smarties Prize, for children's books, three years in a row | 84 |
| First person to travel faster than sound | 40 |
| First person to take a ribbing | 30 |
| First person to reach the North and South Poles | 47 |
| First person to reach the geographic North Pole, he claimed | 59 |
| First person to orbit the Earth | 31 |
| First person to Freud | 21 |
| First person to fly a plane | 27 |
| First person to fly | 19 |
| First person to die | 19 |
| First person to break Mach 1 | 28 |
| First person to be ribbed | 25 |
| First person present, e.g. | 26 |
| First person overseas? | 22 |
| First person outside NASA to receive a moon-rock award, 2006 | 60 |
| First person on a ship? | 23 |
| First person inducted into the Basketball Hall of Fame as both a player and coach | 81 |
| First person indicator | 22 |
| First person in Vienna | 22 |
| First person in the Bible | 25 |
| First person in Potsdam | 23 |
| First person in Germany? | 24 |
| First person in Germany | 23 |
| First person in Frankfurt? | 26 |
| First person in France? | 23 |
| First person in France | 22 |
| First person in Berlin? | 23 |
| First person in Berlin | 22 |
| First person in Austria | 23 |
| First person in ancient Rome | 28 |
| First person | 12 |
| First permanent tooth | 21 |
| First periods in H.S., often | 28 |
| First performance | 17 |
| First people from Manitoba | 26 |
| First penny, perhaps | 20 |
| First peaceful protest? | 23 |
| First Peace Corps director | 26 |
| First PC slot | 13 |
| First passage continued | 23 |
| First part of YSL | 17 |
| First part of V.B.O.B. | 22 |
| First part of the waiter's reply | 36 |
| First part of the quip | 22 |
| First part of the New Testament | 31 |
| First part of the joke | 22 |
| First part of quote | 19 |
| First part of quip | 18 |
| First part of psychosexual development | 38 |
| First part of Miller's "The Rosy Crucifixion" | 59 |
| First part of diner's complaint | 35 |
| First part of an Iowa city | 26 |
| First part of an incomplete stepquote by Rudyard Kipling | 56 |