| Epithet for Clemenceau | 22 |
| Epithet for Anthony Wayne | 25 |
| Epithet for Alexander Pope | 26 |
| Epithet for a Sikh deity | 24 |
| Epithet for a Russian soldier | 29 |
| Epithet for a glasses wearer | 28 |
| Epithet for a famed Briton | 26 |
| Epithet for a computer whiz | 27 |
| Epithet for a Cardinal | 22 |
| Epithet across the pond | 23 |
| Epitaph opener, perhaps | 23 |
| Epistolary courtesy: Abbr. | 26 |
| Epistle of the New Testament | 28 |
| Epistle appendage: Abbr. | 24 |
| Episode of overindulgence | 25 |
| Episcopal jurisdictions | 23 |
| Episcopal chapel leader | 23 |
| Epinephrine-releasing gland | 27 |
| Epinephrine-producing glands | 28 |
| Epinephrine-producing gland | 27 |
| Epilogue or coda, e.g. | 22 |
| Epidemiology org. in Atlanta | 28 |
| Epidemiologist's study | 26 |
| Epidemiologist's concern | 28 |
| Epidemic-fighting org. | 22 |
| Epicurean appreciation | 22 |
| Epicure's condiment | 23 |
| Epic with heroic rebels | 23 |
| Epic with Circe and Penelope | 28 |
| Epic translated by Pope | 23 |
| Epic stories of heroism | 23 |
| Epic starring Achilles | 22 |
| Epic poet-left-behind film? | 27 |
| Epic poem with 9,896 lines | 26 |
| Epic poem with 12 books | 23 |
| Epic poem set in Anatolia | 25 |
| Epic of the Trojan War | 22 |
| Epic involving Agamemnon | 24 |
| Epic featuring Agamemnon | 24 |
| Epic featuring Achilles | 23 |
| Epic containing 24 books | 24 |
| Epic centered on Achilles | 25 |
| Epic about the Trojan War | 25 |
| Epic 1975 showdown, popularly | 29 |
| Ephraim's grandson | 22 |
| Ephemerally brilliant stars | 27 |
| Ephemeral sculpture medium | 26 |
| Ephemeral sculpting medium | 26 |
| Ephemeral heavenly blaze | 24 |
| Ephemeral castle material | 25 |
| EPA's concern, briefly | 26 |
| Eocene and Pleistocene | 22 |
| Enzyme-indicating suffix | 24 |
| Enzyme-forming suffixes | 23 |
| Enzyme used for cheesemaking | 28 |
| Enzyme that curdles milk | 24 |
| Enzyme that catalyzes O2 | 24 |
| Enzyme that can curdle milk | 27 |
| Enzyme that breaks down fats | 28 |
| Enzyme that breaks down fat | 27 |
| Enzyme in fat breakdown | 23 |
| Enzyme formed in kidneys | 24 |
| Enzyme aiding digestion | 23 |
| Enzo Ferrari's language | 27 |
| Enya's kind of music | 24 |
| Enya sometimes sings in it | 26 |
| Envy, wrath or sloth, e.g. | 26 |
| Envy, anger or greed, maybe | 27 |
| Envy or sloth in St. Louis? | 27 |
| Envoy's sheepskin? | 22 |
| Envoy's assignment | 22 |
| Envoy to Russia under F.D.R. | 28 |
| Envision in one's sleep | 27 |
| Environs for thespians | 22 |
| Environs for Galatea, in myth | 29 |
| Environs for Blackbeard | 23 |
| Environmentally-minded | 22 |
| Environmentally minded | 22 |
| Environmentally friendly tote | 29 |
| Environmentally friendly crop | 29 |
| Environmentally friendly auto | 29 |
| Environmentally friendly | 24 |
| Environmentally conscious | 25 |
| Environmentally concerned | 25 |
| Environmentalists' subj. | 28 |
| Environmentalists' org. | 27 |
| Environmentalists' cause | 28 |
| Environmentalist, informally | 28 |
| Environmentalist's urge | 27 |
| Environmentalist's subj. | 28 |
| Environmentalist's sci. | 27 |
| Environmentalist's prefix | 29 |
| Environmentalist's maj. | 27 |
| Environmentalist's goal | 27 |
| Environmentalist Suzuki | 23 |
| Environmentalist Sigurd | 23 |
| Environmentalist group | 22 |
| Environmentalism: Abbr. | 23 |
| Environmental-related prefix | 28 |
| Environmental word form | 23 |