| Highly sought-after item | 24 |
| Highly specific specialties | 27 |
| Highly speculative | 18 |
| Highly spiced | 13 |
| Highly spiced dish | 18 |
| Highly spiced smoked beef | 25 |
| Highly spiced stew | 18 |
| Highly structured 39-line poem | 30 |
| Highly structured echoic poems | 30 |
| Highly stylized sculpting style | 31 |
| Highly successful | 17 |
| Highly successful Hollywood actor James presently on "General Hospital" | 81 |
| Highly successful reviews | 25 |
| Highly successful, in Varietyese | 32 |
| Highly thought of | 17 |
| Highly timely | 13 |
| Highly toxic environmental pollutants, for short | 48 |
| Highly toxic pollutants | 23 |
| Highly uncertain | 16 |
| Highly uncommon | 15 |
| Highly unconventional | 21 |
| Highly unlikely to change | 25 |
| Highly unlikely, as a chance | 28 |
| Highly unlikely, as chances | 27 |
| Highly unskilled servers? | 25 |
| Highly unusual | 14 |
| Highly unusual event | 20 |
| Highly valued | 13 |
| Highly valued asset, and this puzzle's title | 48 |
| Highly valued fertilizer | 24 |
| Highly valued land, say | 23 |
| Highly veined, as flies' wings | 34 |
| Highly venomous snake | 21 |
| Highly venomous snakes | 22 |
| Highly venomous stinger | 23 |
| Highly vigilant | 15 |
| Highly volatile fuel: Abbr. | 27 |
| Highly volatile gas, for short | 30 |
| Highly volatile hydrocarbon | 27 |
| Highly worried | 14 |
| Highly wrought | 14 |
| Highly-glazed fabrics | 21 |
| Highly-placed pop singer? | 25 |
| Highly-prized muscle cars | 25 |
| Highly-ranked golfer | 20 |
| Highly-ranked noncoms | 21 |
| Highly-rated | 12 |
| Highly-touted NBC spinoff cancelled in 2008 before production | 61 |
| Highminded | 10 |
| Highness | 8 |
| Highness: Abbr. | 15 |
| Highpointer's destination in Ore. | 37 |
| Highrise dwellings: Abbr. | 25 |
| Highrise in nature | 18 |
| Highs | 5 |
| Highs and lows | 14 |
| Highs and lows, perhaps | 23 |
| Highs' opposites | 20 |
| Highschooler | 12 |
| Highschooler's option: abbr. | 32 |
| Highsmith's amoral protagonist | 34 |
| Highstrung | 10 |
| Hightail | 8 |
| Hightail it | 11 |
| Hightail it away | 16 |
| Hightail it out | 15 |
| Hightail it, old-style | 22 |
| Hightailed it | 13 |
| Hightails | 9 |
| Hightails it | 12 |
| Highway | 7 |
| Highway 1 city | 14 |
| Highway abbreviation | 20 |
| Highway access | 14 |
| Highway accesses | 16 |
| Highway accident consequences | 29 |
| Highway ad sign | 15 |
| Highway adjoiner | 16 |
| Highway advisory | 16 |
| Highway approaches | 18 |
| Highway areas | 13 |
| Highway bailout | 15 |
| Highway barrier | 15 |
| Highway behemoth | 16 |
| Highway behemoths | 17 |
| Highway billboard words | 23 |
| Highway blight | 14 |
| Highway bottleneck | 18 |
| Highway breaker? | 16 |
| Highway breakfast joints | 24 |
| Highway bypass, usually | 23 |
| Highway caution | 15 |
| Highway caution sign | 20 |
| Highway chatterbox | 18 |
| Highway cloverleaf principle | 28 |
| Highway clunkers | 16 |
| Highway connection | 18 |
| Highway construction crew's supplies | 40 |
| Highway construction crews | 26 |
| Highway construction machine | 28 |