| Difficult choice | 16 |
| Difficult challenge | 19 |
| Difficult burdens | 17 |
| Difficult burden | 16 |
| Difficult billiards shot | 24 |
| Difficult beast to ride into battle? | 36 |
| Difficult assignment | 20 |
| Difficult articulations | 23 |
| Difficult and unpleasant | 24 |
| Difficult and loathsome | 23 |
| Difficult and distasteful | 25 |
| Difficult age | 13 |
| Difficult to a Cockney | 23 |
| Difficult | 9 |
| Differs in opinion | 18 |
| Differs | 7 |
| Differing: Abbr. | 16 |
| Differing | 9 |
| Differin target, slangily | 25 |
| Differently: Abbr. | 18 |
| Differently -- (having other skills) | 36 |
| Differently | 11 |
| Differentiate | 13 |
| Differential-gear locale | 24 |
| Differential or integral math subj. | 35 |
| Differential in solar and lunar time | 36 |
| Differential gear's spot | 28 |
| Differential gear's place | 29 |
| Differential gear site | 22 |
| Differential fluid's place | 30 |
| Differential component | 22 |
| Differential attachment | 23 |
| Different: Prefix | 17 |
| Different: Lat. | 15 |
| Different: Comb. form | 21 |
| Different's antonym | 23 |
| Different take | 14 |
| Different spelling: Abbr. | 25 |
| Different spelling, in crosswords: abbr. | 40 |
| Different sp. | 13 |
| Different slant | 15 |
| Different roles, so to speak | 28 |
| Different roles, metaphorically | 31 |
| Different roles, in metaphor | 28 |
| Different ones are hidden in 12 starred answers | 47 |
| Different ones | 14 |
| Different kinds of them are split (but not in an embarrassing way) in the four starred answers | 94 |
| Different in nature | 19 |
| Different genres | 16 |
| Different from what's expected | 34 |
| Different from that | 19 |
| Different from before | 21 |
| Different from | 14 |
| Different ending? | 17 |
| Different ending | 16 |
| Different cuts | 14 |
| Different aspect | 16 |
| Different | 9 |
| Differences of opinion | 22 |
| Differences between age groups | 30 |
| Difference of opinion | 21 |
| Difference in days between the lunar and solar year | 51 |
| Difference in apparent direction, in astronomy | 46 |
| Difference in a close race | 26 |
| Difference in a close ball game | 31 |
| Difference between winners and losers? | 38 |
| Difference between the rich and the poor | 40 |
| Difference between the ai and the unau | 38 |
| Difference between prices bid and asked | 39 |
| Difference between money coming in and money being spent | 56 |
| Difference between men and women | 32 |
| Difference between gross and net weight | 39 |
| Difference between generations | 30 |
| Difference between Gen-Xers and baby boomers | 44 |
| Difference between a lot and a little, maybe | 44 |
| Difference between a baker's dozen and a dozen | 50 |
| Difference between 19 and 21 | 28 |
| Difference | 10 |
| Differ or depend ending | 23 |
| Differ follower | 15 |
| Differ finish | 13 |
| Differ ender | 12 |
| Differ amicably | 15 |
| Differ | 6 |
| Diff. spelling | 14 |
| Diez x diez, sometimes | 22 |
| Diez x diez | 11 |
| Diez minus tres | 15 |
| Diez minus dos | 14 |
| Dieu et ___ droit (motto of England) | 36 |
| Diety with a hammer | 19 |
| Diets successfully, with "down" | 41 |
| Diets successfully | 18 |
| Diets strenuously | 17 |
| Diets drastically | 17 |
| Diets | 5 |
| Dietrich's nickname for Hemingway | 37 |
| Dietrich's namesakes | 24 |
| Dietrich's Marlene | 22 |
| Dietrich vehicle, with "The" | 38 |