| Upper reaches of space | 22 |
| Upper regions of space | 22 |
| Upper Thames or goddess | 23 |
| Upper ___ (now Burkina Faso) | 28 |
| Upper ___, African republic | 27 |
| Upper, in Upper Westphalia | 26 |
| Upper-case facilitators | 23 |
| Upper-case letters: Abbr. | 25 |
| Upper-echelon employees | 23 |
| Upper-house action: Abbr. | 25 |
| Upper-house members: Abbr. | 26 |
| Upper-left button on a phone | 28 |
| Upper-left computer key | 23 |
| Upper-left keyboard key | 23 |
| Upper-level math subj. | 22 |
| Upper-level storage area | 24 |
| Upper-___ (junior or senior) | 28 |
| Uppercase aitch lookalike | 25 |
| Uppercase letters, briefly | 26 |
| Uppercase letters, for short | 28 |
| Uppercase only, to eds. | 23 |
| Upperclassmen, at times | 23 |
| Uppermost number, sometimes | 27 |
| Upright basketball player? | 26 |
| Upright Gary Numan song | 23 |
| Upright member of a frame | 25 |
| Upright monumental stone | 24 |
| Upright stone monument | 22 |
| Uprights on staircases | 22 |
| Upriser, put pejoratively | 25 |
| Uprising at Leavenworth, e.g. | 29 |
| Uproar over a disputed matter | 29 |
| Uproariously funny sort | 23 |
| UPS alternative, originally | 27 |
| Ups and downs of exercise? | 26 |
| Ups and downs of fashion | 24 |
| UPS driver's assignment | 27 |
| UPS driver's device | 23 |
| UPS drop-off site, often | 24 |
| UPS shipping price factor | 25 |
| Upscale apartment feature | 25 |
| Upscale buffet section | 22 |
| Upscale eatery handout | 22 |
| Upscale electronics company | 27 |
| Upscale golfwear brand | 22 |
| Upscale hotel chain name | 24 |
| Upscale hotel offering | 22 |
| Upscale hotel room features | 27 |
| Upscale inexpensive book? | 25 |
| Upscale Italian fashion brand | 29 |
| Upscale Italian fashion house | 29 |
| Upscale Italian shoe brand | 26 |
| Upscale Italian shoe make | 25 |
| Upscale kitchen feature | 23 |
| Upscale living quarters | 23 |
| Upscale London district | 23 |
| Upscale office décor | 23 |
| Upscale retailer __ Marcus | 26 |
| Upscale retailer ___ Marcus | 27 |
| Upscale Roman shopping street | 29 |
| Upscale state of India | 22 |
| Upset a stage coach, perhaps | 28 |
| Upset stomach reliever | 22 |
| Upset the Yankee Clipper | 24 |
| Upset, with "out" | 27 |
| Upset, with "up" | 26 |
| Upsets anthills, in a way | 25 |
| Upsetting pantry presence | 25 |
| Upshot of bad service, maybe | 28 |
| Upshot of muralist's work | 29 |
| Upshot of poor service | 22 |
| Upshot of writer's block | 28 |
| Upside-down "e" | 25 |
| Upside-down branch hanger | 25 |
| Upside-down-sleeping mammal | 27 |
| Upsilon's follower | 22 |
| Upsilon's preceder | 22 |
| Upsilon's successor | 23 |
| Upstage a co-star, perhaps | 26 |
| Upstage everyone, maybe | 23 |
| Upstages a performer, e.g. | 26 |
| Upstairs area of a home | 23 |
| Upstairs storage space | 22 |
| Upstanding Chinese feature? | 27 |
| Upstart business, casually | 26 |
| Upstate N.Y. lake group | 23 |
| Upstate N.Y. resort area | 24 |
| Upstate New York city and spa | 29 |
| Upstate New York county | 23 |
| Upstate New York natives | 24 |
| Upstate New York prison | 23 |
| Uptight motion of the hands | 27 |
| Upton Sinclair masterwork | 25 |
| Upton Sinclair subject | 22 |
| Upton Sinclair's Budd | 25 |
| Upton Sinclair's Mr. Budd | 29 |
| Uptown's dir. in N.Y.C. | 27 |
| Upturn, in Wall St. parlance | 28 |
| Upward curve in timber | 22 |
| Upward curves on planks | 23 |