| First U.S. space traveler | 25 |
| First U.S. spaceman | 19 |
| First U.S. spacewalk mission | 28 |
| First U.S. state | 16 |
| First U.S. state to abolish slavery | 35 |
| First U.S. vice president | 25 |
| First U.S. vice president not to become president | 49 |
| First U.S. woman governor __ Tayloe Ross | 40 |
| First U.S. woman in space | 25 |
| First U.S. women's college | 30 |
| First U.S.-born saint | 21 |
| First UN secretary-general | 26 |
| First unelected president | 25 |
| First unelected U.S. president | 30 |
| First United States vice president | 34 |
| First up | 8 |
| First up, Marc____ | 18 |
| First US space station | 22 |
| First US university to award a Ph.D. | 36 |
| First US vice president | 23 |
| First US-born saint | 19 |
| First utopia | 12 |
| First V.P. | 10 |
| First variable star to be discovered | 36 |
| First veep | 10 |
| First vehicle in a funeral procession | 37 |
| First vehicle, often | 20 |
| First version | 13 |
| First version of a film | 23 |
| First vertebra | 14 |
| First vice president | 20 |
| First victim | 12 |
| First victim of fratricide | 26 |
| First victim of sibling rivalry | 31 |
| First victim of temptation | 26 |
| First victim's namesakes | 28 |
| First video arcade game | 23 |
| First video broadcast on MTV2 (8/1/96) | 38 |
| First video game with a selectable level of difficulty | 54 |
| First Virginia in America | 25 |
| First Viscount Templewood | 25 |
| First voice of Mickey Mouse | 27 |
| First volume | 12 |
| First volume heading starter | 28 |
| First volume of an encyclopedia, perhaps | 40 |
| First watch on the moon | 23 |
| First weapon to be electrified | 30 |
| First weather Satellites | 24 |
| First West German chancellor | 28 |
| First Western televised in color | 32 |
| First wheels | 12 |
| First wheels, often | 19 |
| First White House golfer | 24 |
| First White House occupant | 26 |
| First wicked place? | 19 |
| First wife | 10 |
| First wife of Bill on HBO's "Big Love" | 52 |
| First wife of Jacob | 19 |
| First wife of Julius Caesar | 27 |
| First wife of Shiva | 19 |
| First wife of Woodrow Wilson | 28 |
| First winner of a Best Animated Feature Oscar | 45 |
| First winner of consecutive Oscars | 34 |
| First winner of the Academy Award for Best Picture | 50 |
| First winning number? | 21 |
| First wireless telegrapher | 26 |
| First with headlight wipers | 27 |
| First Wives Club star | 24 |
| First woman | 11 |
| First woman astronaut | 21 |
| First woman attorney general | 28 |
| First woman director of the U.S. Mint | 37 |
| First woman director of U.S. Mint | 33 |
| First woman elected governor | 28 |
| First woman governor | 20 |
| First woman in Parliament | 25 |
| First woman in the British Parliament | 37 |
| First woman in the House of Commons | 35 |
| First woman M.P. of England | 27 |
| First woman on Earth | 20 |
| First woman on the Supreme Court | 32 |
| First woman Supreme Court Justice, _____ Day O'Connor | 57 |
| First woman to appear on the front of a Wheaties box | 52 |
| First woman to be named Attorney General | 40 |
| First woman to earn the Distinguished Flying Cross | 50 |
| First woman to fly across the Atlantic | 38 |
| First woman to govern a state | 29 |
| First woman to host the Oscars solo | 35 |
| First woman to land a triple axel in a major competition | 56 |
| First woman to land a triple axel in competition | 48 |
| First woman to lead a seat-winning Federal Party | 48 |
| First woman to receive the Pulitzer Prize for Poetry | 52 |
| First woman to sit as a member of Parliament | 44 |
| First woman to sit in Parliament | 32 |
| First woman to sit in the British House of Commons | 50 |
| First woman to swim the English Channel | 39 |
| First woman to teach at the Sorbonne | 36 |
| First woman to win Best Director | 32 |
| First woman, in Greek myth | 26 |
| First women's champ: 1946 | 29 |