| Isogram | 7 |
| Isolate | 7 |
| Isolate a crime scene | 21 |
| Isolate again, as a beat | 24 |
| Isolate during the winter | 25 |
| Isolate during winter | 21 |
| Isolate like Gilligan | 21 |
| Isolate like Napoleon | 21 |
| Isolate, as Napoleon | 20 |
| Isolate, as Napoleon Bonaparte | 30 |
| Isolate, due to a blizzard | 26 |
| Isolate, emotionally | 20 |
| Isolate, in a way | 17 |
| Isolate, old style | 18 |
| Isolate, possibly | 17 |
| Isolate, somehow | 16 |
| Isolate, with "off" | 29 |
| Isolated | 8 |
| Isolated (with ''off'') | 39 |
| Isolated and dangerous | 22 |
| Isolated appearance | 19 |
| Isolated area | 13 |
| Isolated areas of vegetation | 28 |
| Isolated community | 18 |
| Isolated districts | 18 |
| Isolated fertile areas | 22 |
| Isolated flare up disrupted by expedition (11) | 46 |
| Isolated flattop | 16 |
| Isolated French places | 22 |
| Isolated from others | 20 |
| Isolated haven | 14 |
| Isolated hill | 13 |
| Isolated hill surrounded by lava | 32 |
| Isolated hills | 14 |
| Isolated instance | 17 |
| Isolated land | 13 |
| Isolated locales | 16 |
| Isolated mathematical point | 27 |
| Isolated nest | 13 |
| Isolated nest: Var. | 19 |
| Isolated or insulated | 21 |
| Isolated PC key | 15 |
| Isolated place | 14 |
| Isolated places | 15 |
| Isolated plateau | 16 |
| Isolated prison area (represented by this 4x4 corner) from which the solver must escape | 87 |
| Isolated region | 15 |
| Isolated rock | 13 |
| Isolated rocks | 14 |
| Isolated spot/Boardwalk area | 28 |
| Isolated valley | 15 |
| Isolated, (with "off") | 32 |
| Isolated, and feeling it | 24 |
| Isolated, as a people | 21 |
| Isolated, in a way | 18 |
| Isolated, peaceful rural places | 31 |
| Isolated, with "off" | 30 |
| Isolates | 8 |
| Isolates, as one from among many | 32 |
| Isolating | 9 |
| Isolating tactics | 17 |
| Isolation | 9 |
| Isolation is his delectation | 28 |
| Isolationist in the Senate: 1925–45 | 42 |
| Isolationist's bane | 23 |
| Isolde's beloved | 20 |
| Isolde's love | 17 |
| Isolde's lover | 18 |
| Isole ___ (isles off Sicily) | 28 |
| Isomer found in rubber cement | 29 |
| Isomeric | 8 |
| Isometric | 9 |
| Isopods | 7 |
| Isopods known as roly-polies | 28 |
| Isopyre, e.g. | 13 |
| Isosceles for one | 18 |
| Isosceles, for one | 18 |
| Isotonic solution | 17 |
| Isotope of hydrogen | 19 |
| Isotope of thorium | 18 |
| Isotope units | 13 |
| Isotope, e.g. | 13 |
| Isotopes | 8 |
| ISP choice | 10 |
| ISP featuring CBS Radio stations | 32 |
| ISP founded by Steve Case | 25 |
| ISP founded in 1998 | 19 |
| ISP giant | 9 |
| ISP of note | 11 |
| ISP offering | 12 |
| ISP option | 10 |
| ISP that debuted with Windows 95 | 32 |
| ISP that owns Moviefone | 23 |
| ISP that used to mail free trial discs | 38 |
| ISP with a butterfly logo | 25 |
| ISP with a circle-in-a-triangle logo | 36 |
| ISP with chat rooms | 19 |
| ISP with IMs | 12 |
| ISP with Instant Messages | 25 |
| ISP with Instant Messenger | 26 |