| Missouri metropolis, familiarly | 31 |
| Missouri metro | 14 |
| Missouri is beginning to turn humid (5) | 39 |
| Missouri initials | 17 |
| Missouri Indians | 16 |
| Missouri Indian relative | 24 |
| Missouri Indian | 15 |
| Missouri hrs. | 13 |
| Missouri feeder | 15 |
| Missouri end of the Pony Express | 32 |
| Missouri county on the border of Arkansas | 41 |
| Missouri county | 15 |
| Missouri Compromise signer | 26 |
| Missouri clock setting: Abbr. | 29 |
| Missouri city, locally | 22 |
| Missouri city, informally | 25 |
| Missouri city, for short | 24 |
| Missouri city, familiarly | 25 |
| Missouri city, briefly | 22 |
| Missouri city where Jesse James was killed | 42 |
| Missouri city nickname | 22 |
| Missouri city | 13 |
| Missouri campus town | 20 |
| Missouri branch | 15 |
| Missouri birthplace of H.S.T. | 29 |
| Missouri birds | 14 |
| Missouri bird? | 14 |
| Missouri bird | 13 |
| Missouri band that tried to "shake things up" | 55 |
| Missouri band that failed to "shake things up" | 56 |
| Missouri ballplayer's connection? | 37 |
| Missouri baby carriers? | 23 |
| Missouri and Ohio | 17 |
| Missoula-to-Boise dir. | 22 |
| Missle housing | 14 |
| Missives | 8 |
| Missive: Abbr. | 14 |
| Missive with kisses? | 20 |
| Missive whose meaning is often blurred by autocorrect | 53 |
| Missive to a celeb | 18 |
| Missive to a 1-A | 16 |
| Missive that's not massive | 30 |
| Missive leading to military service | 35 |
| Missive from a smartphone, say | 30 |
| Missive | 7 |
| Mississippi-to-Michigan dir. | 28 |
| Mississippi-Missouri, in U.S.A. | 31 |
| Mississippi-born TV mogul | 25 |
| Mississippi, to a mademoiselle | 30 |
| Mississippi, the ___ State | 26 |
| Mississippi, e.g. | 17 |
| Mississippi's ___ State University | 38 |
| Mississippi's ___ River | 27 |
| Mississippi's Trent | 23 |
| Mississippi's state tree | 28 |
| Mississippi's state flower | 30 |
| Mississippi's source lake | 29 |
| Mississippi's official airline? | 35 |
| Mississippi's mouth | 23 |
| Mississippi's junior senator | 32 |
| Mississippi's four: Abbr. | 29 |
| Mississippi's four | 22 |
| Mississippi's capital | 25 |
| Mississippi ___ | 15 |
| Mississippi who? | 16 |
| Mississippi waterway | 20 |
| Mississippi vessel | 18 |
| Mississippi Valley deposit | 26 |
| Mississippi university that's home to the Fighting Okra | 59 |
| Mississippi tributary named by La Salle | 39 |
| Mississippi tributary in Mississippi | 36 |
| Mississippi tributary | 21 |
| Mississippi triangle | 20 |
| Mississippi traveler | 20 |
| Mississippi town in "In the Heat of the Night" | 56 |
| Mississippi takes four | 22 |
| Mississippi source | 18 |
| Mississippi site of Machine Gun Kelly's last known bank robbery | 67 |
| Mississippi sights | 18 |
| Mississippi sight | 17 |
| Mississippi setting? | 20 |
| Mississippi senator's family | 32 |
| Mississippi Senator _____ Lott | 30 |
| Mississippi senator will catch on? | 34 |
| Mississippi senator Trent | 25 |
| Mississippi senator Cochran | 27 |
| Mississippi senator | 19 |
| Mississippi rodent, say | 23 |
| Mississippi River's largest tributary | 41 |
| Mississippi River vis-a-vis Mississippi | 39 |
| Mississippi River vessel | 24 |
| Mississippi River transport | 27 |
| Mississippi river to the Mississippi River | 42 |
| Mississippi River source | 24 |
| Mississippi River sight | 23 |
| Mississippi river named by La Salle | 35 |
| Mississippi River flatboat | 26 |
| Mississippi River feature | 25 |
| Mississippi River explorer | 26 |
| Mississippi River discoverer of 1541 | 36 |