| Isle of ____ | 12 |
| Isle of _____ | 13 |
| Isle of _____, England | 22 |
| Isle off coast of Ireland | 25 |
| Isle off England | 16 |
| Isle off Italy | 14 |
| Isle off Labrador | 17 |
| Isle off New Caledonia | 22 |
| Isle off Sicily | 15 |
| Isle off the lower boot | 23 |
| Isle off Tuscany | 16 |
| Isle off Venezuela | 18 |
| Isle on the Gulf of Naples | 26 |
| Isle on the Ouse | 16 |
| Isle on which Apollo was born | 29 |
| Isle or City | 12 |
| Isle or terrier | 15 |
| Isle ruled by Morgan le Fay | 27 |
| Isle serenaded in "South Pacific" | 43 |
| Isle surrounder | 15 |
| Isle used as a base by Xerxes | 29 |
| Isle where Homer is buried, supposedly | 38 |
| Isle where Macbeth is buried | 28 |
| Isle where Napoleon was exiled | 30 |
| Isle where Saint Columba died | 29 |
| Isle where several Scottish kings are buried | 44 |
| Isle with a lagoon | 18 |
| Isle __ National Park | 21 |
| Isle ___ | 8 |
| Isle ___ (site off England) | 27 |
| Isle ___ National Park | 22 |
| Isle: Var. | 10 |
| Isled | 5 |
| Isles | 5 |
| Isles in Malay Archipelago | 26 |
| Isles of __: Gulf of Maine locale | 33 |
| Isles off Ireland | 17 |
| Islet | 5 |
| Islet (British) | 15 |
| Islet in a British river | 24 |
| Islet in a river, OE | 20 |
| Islet in la mer | 15 |
| Islet, to Giselle | 17 |
| Islet: Fr. | 10 |
| Islet: Sp. | 10 |
| Islet: Var. | 11 |
| Islets | 6 |
| Islets of Langerhans locale | 27 |
| Islets on maps | 14 |
| Isley Brother | 13 |
| Isley Brothers classic | 22 |
| Isley Brothers hit "___ Lady" | 39 |
| Isley that sang with Rod on "This Old Heart of Mine" | 62 |
| Isle_____ | 9 |
| Isls. NE of Australia | 21 |
| Ism | 3 |
| Ismail's title | 18 |
| Ismaili leader | 14 |
| Ismene's father | 19 |
| Isms | 4 |
| Isn't on the street | 24 |
| Isn't wrong | 16 |
| Isn't a benchwarmer | 23 |
| Isn't a fad | 15 |
| Isn't a loser | 17 |
| Isn't a natural | 19 |
| Isn't a natural blonde | 26 |
| Isn't able | 14 |
| Isn't able to | 17 |
| Isn't absorbed | 18 |
| Isn't alert | 15 |
| Isn't all the same | 22 |
| Isn't amiss? | 16 |
| Isn't an odd one out | 24 |
| Isn't an outsider | 21 |
| Isn't any more | 18 |
| Isn't anymore | 17 |
| Isn't apathetic | 19 |
| Isn't around now | 20 |
| Isn't at all fair | 21 |
| Isn't blind to | 18 |
| Isn't blocked, as a signal | 30 |
| Isn't bold | 14 |
| Isn't bothered by | 21 |
| Isn't bothered by adversity | 31 |
| Isn't busy | 14 |
| Isn't buying it? | 20 |
| Isn't candid with | 21 |
| Isn't capable of | 20 |
| Isn't caught by | 19 |
| Isn't caught up | 19 |
| Isn't clear in speech, maybe | 32 |
| Isn't clueless | 18 |
| Isn't colorfast | 19 |
| Isn't complete without | 26 |
| Isn't completely honest with | 32 |
| Isn't consistent | 20 |
| Isn't conspicuous | 21 |
| Isn't content with the status quo, say | 42 |
| Isn't correct | 17 |