| Isaac Asimov book made into a 2004 Will Smith film | 50 |
| Isaac Asimov character | 22 |
| Isaac Asimov classic | 20 |
| Isaac Asimov mystery "Murder at the ___" | 50 |
| Isaac Asimov novel | 18 |
| Isaac Asimov wore one | 21 |
| Isaac Asimov wore them | 22 |
| Isaac Asimov's "Murder at the ___" | 48 |
| Isaac Asimov's birthplace | 29 |
| Isaac Asimov's genre | 24 |
| Isaac Asimov, notably | 21 |
| Isaac Bashevis Singer character | 31 |
| Isaac Bashevis Singer novel | 27 |
| Isaac Bashevis Singer settings | 30 |
| Isaac Bashevis Singer story "___ the Yeshiva Boy" | 59 |
| Isaac Bashevis Singer's "Yeshiva Boy" | 51 |
| Isaac Bashevis Singer's language | 36 |
| Isaac Bickerstaff | 17 |
| Isaac Bickerstaff was one of his pen names | 42 |
| Isaac Brock side project ___ Casanova | 37 |
| Isaac Brock's "Casanova" | 38 |
| Isaac Caesar's stage name | 29 |
| Isaac Hayes did its theme song | 30 |
| Isaac Hayes soundtrack | 22 |
| Isaac Newton's inspiration | 30 |
| Isaac Newton, e.g. | 18 |
| Isaac of fiddledom | 18 |
| Isaac of music | 14 |
| Isaac of sci-fi | 15 |
| Isaac or Helen | 14 |
| Isaac or Howard | 15 |
| Isaac or Wayne | 14 |
| Isaac Singer's last novel | 29 |
| Isaac Singer's rival Howe | 29 |
| Isaac Stern contemporary | 24 |
| Isaac Stern contemporary (after using a pull down menu) | 55 |
| Isaac Stern stroke | 18 |
| Isaac Stern's instrument | 28 |
| Isaac Stern, for one | 20 |
| Isaac the violinist | 19 |
| Isaac who wrote himself into "Murder at the ABA" | 58 |
| Isaac Wise, e.g. | 16 |
| Isaac with a bow | 16 |
| Isaac with a violin | 19 |
| Isaac's best friend in "Manhattan" | 48 |
| Isaac's boorish kid | 23 |
| Isaac's elder son | 21 |
| Isaac's eldest | 18 |
| Isaac's eldest son | 22 |
| Isaac's father | 18 |
| Isaac's father in the Old Testament | 39 |
| Isaac's first | 17 |
| Isaac's first son | 21 |
| Isaac's first-born | 22 |
| Isaac's firstborn | 21 |
| Isaac's glances? | 20 |
| Isaac's mother | 18 |
| Isaac's mother: Var. | 24 |
| Isaac's older son | 21 |
| Isaac's oldest | 18 |
| Isaac's son | 15 |
| Isaac's son and others | 26 |
| Isaac's son et al. | 22 |
| Isaac, familiarly | 18 |
| Isaac, for short | 16 |
| Isaac, informally | 17 |
| Isaac, to Abraham | 17 |
| Isaac, to his friends | 21 |
| Isaac, to Jacob | 15 |
| IsaacÂ's eldest | 23 |
| Isaak Babel book | 16 |
| Isabel Allende title | 20 |
| Isabel Allende's "Eva ___" | 40 |
| Isabel Allende's "La Casa de ___ Espiritus" | 57 |
| Isabel Allende's "___ of My Soul" | 47 |
| Isabel Allende's birthplace | 31 |
| Isabel II was one | 17 |
| Isabel II, e.g. | 15 |
| Isabel or Eva | 13 |
| Isabel or Juan | 14 |
| Isabel Perón, e.g. | 21 |
| Isabel was one | 14 |
| Isabel who co-starred in "The Jeffersons" | 51 |
| Isabel's center | 19 |
| Isabel, e.g. | 12 |
| Isabel, for one | 15 |
| Isabel, Juan, or Eva | 20 |
| Isabel, por ejemplo | 19 |
| Isabella and Sofia | 18 |
| Isabella d' ____ | 20 |
| Isabella d'___ | 18 |
| Isabella d'___ (famed beauty) | 33 |
| Isabella d'___ (Titian subject) | 35 |
| Isabella d'___, Leonardo subject | 36 |
| Isabella d'___, patron of Leonardo | 38 |
| Isabella II, por ejemplo | 24 |
| Isabella Rossellini's father | 32 |
| Isabella's "is" | 29 |
| Isabella's home | 19 |
| Isabella's home in Seville | 30 |