| Early seducee | 13 |
| Early self-help guru | 20 |
| Early Semite | 12 |
| Early Semitic language | 22 |
| Early September observance | 26 |
| Early September wedding? | 24 |
| Early serf | 10 |
| Early serfs | 11 |
| Early settler | 13 |
| Early settler of England | 24 |
| Early settlers in the Orkneys | 29 |
| Early settlers of Iceland | 25 |
| Early settlers' beef | 24 |
| Early seventh century date | 26 |
| Early seventh-century date | 26 |
| Early seventh-century year | 26 |
| Early shafted weapon | 20 |
| Early Shakespearean tragedy | 27 |
| Early Shaw play | 15 |
| Early shelter | 13 |
| Early shepherd | 14 |
| Early ship reaching American shores | 35 |
| Early shipbuilder | 17 |
| Early Shirley role | 18 |
| Early shopping mall | 19 |
| Early show | 10 |
| Early show of interest | 22 |
| Early show? | 11 |
| Early shows | 11 |
| Early sibling rivalry victim | 28 |
| Early sickness symptom | 22 |
| Early sign of dissent | 21 |
| Early sign of spring | 20 |
| Early Sinatra employer | 22 |
| Early sinner | 12 |
| Early sitcom couple | 19 |
| Early sitcom star | 17 |
| Early sitcom star Desi | 22 |
| Early sixth-century date | 24 |
| Early sixth-century year | 24 |
| Early skipper | 13 |
| Early Slav rulers | 17 |
| Early slave | 11 |
| Early slaves | 12 |
| Early Slavonic ruler's title | 32 |
| Early smartphone | 16 |
| Early Smashing Pumpkins album | 29 |
| Early sneaker brand | 19 |
| Early SNL star | 14 |
| Early soap powder | 17 |
| Early Socialist presidential candidate Eugene | 45 |
| Early software version | 22 |
| Early software versions | 23 |
| Early source of nourishment | 27 |
| Early source of oil | 19 |
| Early source of spices, with "the" | 44 |
| Early South African prime minister Jan | 38 |
| Early South American | 20 |
| Early South American empire | 27 |
| Early South Carolina senator Thomas | 35 |
| Early southern Europeans | 24 |
| Early Soviet leader | 19 |
| Early Soviet space probe | 24 |
| Early Soviet space program | 26 |
| Early Soviet spacecraft series | 30 |
| Early space chimp | 17 |
| Early space explorer Shepard | 28 |
| Early space mission | 19 |
| Early space traveler | 20 |
| Early space travelers | 21 |
| Early specimen of Homo erectus | 30 |
| Early spreader of the gospel | 28 |
| Early spring bloom | 18 |
| Early spring bloomer | 20 |
| Early spring bloomers | 21 |
| Early spring blooms | 19 |
| Early spring feast | 18 |
| Early spring flower | 19 |
| Early spring flowers | 20 |
| Early spring relatives of irises | 32 |
| Early spring relatives of irises (Var.) | 39 |
| Early spring scoldings? | 23 |
| Early spring shout | 18 |
| Early spring sights? | 20 |
| Early spring sign | 17 |
| Early stable man | 16 |
| Early stage | 11 |
| Early stage of a manuscript | 27 |
| Early stage of a time capsule project | 37 |
| Early stage of a tourney | 24 |
| Early stage of development | 26 |
| Early stage of industrial work, for short | 41 |
| Early stage seed | 16 |
| Early stages | 12 |
| Early star trekkers | 19 |
| Early stargazers? | 17 |
| Early start | 11 |
| Early start? | 12 |
| Early starter | 13 |
| Early state in presidential campaigns | 37 |