| African ravines | 15 |
| African reed instruments | 24 |
| African reedbucks | 17 |
| African region | 14 |
| African region including Khartoum and Timbuktu | 46 |
| African region totaling 1.2 million square miles | 48 |
| African reptiles | 16 |
| African republic | 16 |
| African republic (formerly) | 27 |
| African republic colonized by freed American slaves | 51 |
| African republic inhabitant | 27 |
| African republic or lake | 24 |
| African republic with the motto "Victory is ours" | 59 |
| African republic: Fr. | 21 |
| African river | 13 |
| African river featuring Victoria Falls | 38 |
| African river on Saint-Exupéry's journey | 47 |
| African river or country | 24 |
| African river or Italian physicist | 34 |
| African river or lake | 21 |
| African river or land | 21 |
| African river that runs through ten countries | 45 |
| African river that two capitals are on | 38 |
| African river that's the world's deepest | 48 |
| African roarer | 14 |
| African robe at the U.N. | 24 |
| African rodent | 14 |
| African ruler | 13 |
| African ruler? | 14 |
| African rulers | 14 |
| African ruminant | 16 |
| African runner | 14 |
| African salt bed | 16 |
| African sands | 13 |
| African scavenger | 17 |
| African scavengers | 18 |
| African scourge | 15 |
| African seceder of 1993 | 23 |
| African secessionist state: 1967-70 | 35 |
| African secret society | 22 |
| African serpent | 15 |
| African serpents | 16 |
| African sheep | 13 |
| African shrub | 13 |
| African shrub in the lily family | 32 |
| African skunk | 13 |
| African sleep-inducer | 21 |
| African slitherer | 17 |
| African snake | 13 |
| African snakes | 14 |
| African snapper | 15 |
| African soccer powerhouse popularly known as the Black Stars | 60 |
| African soldier | 15 |
| African sorceress of fiction | 28 |
| African sorcery | 15 |
| African spear | 13 |
| African spear: Var. | 19 |
| African spears | 14 |
| African spirit | 14 |
| African spread | 14 |
| African sprinter | 16 |
| African state | 13 |
| African stockade | 16 |
| African stream | 14 |
| African streambed | 17 |
| African succulent | 17 |
| African succulents | 18 |
| African tableland | 17 |
| African tablelands | 18 |
| African tea leaves | 18 |
| African tea leaves (Var.) | 25 |
| African teas | 12 |
| African term of address | 23 |
| African terrain | 15 |
| African thong | 13 |
| African threat | 14 |
| African timber tree | 19 |
| African title | 13 |
| African title of respect | 24 |
| African tongue | 14 |
| African tongue: Var. | 20 |
| African trade language | 22 |
| African tree | 12 |
| African tree snake | 18 |
| African trees | 13 |
| African trees with nutlike seeds | 32 |
| African trees with thick trunks | 31 |
| African trek | 12 |
| African tribal group | 20 |
| African tribe | 13 |
| African tribe member | 20 |
| African tribesman | 17 |
| African tribesmen | 17 |
| African trumpeter | 17 |
| African trumpeters | 18 |
| African Tuber | 13 |
| African tumbler | 15 |
| African tyrant and namesakes | 28 |
| African ungulates | 17 |
| African Union chairman elected in 2009 | 38 |