| First Canadian to run the mile in under 4 minutes | 49 |
| First Canadian winner at Augusta | 32 |
| First Canadian woman atop Everest | 33 |
| First Canadian-born Governor General | 36 |
| First canonical hour | 20 |
| First canonized native-born American | 36 |
| First Canuck satellite to fly | 29 |
| First capital | 13 |
| First capital of Alaska | 23 |
| First capital of California | 27 |
| First capital of Japan | 22 |
| First capital of the kingdom of Italy | 37 |
| First capital of the Last Frontier | 34 |
| First capital of unified Italy | 30 |
| First car, for many | 19 |
| First car, for many? | 20 |
| First car, often | 16 |
| First card below the faces | 26 |
| First card played in the game parliament | 40 |
| First card turned up in a game of faro | 38 |
| First cardinal in Mexico | 24 |
| First carrier to offer commercial transpolar flights | 52 |
| First carrier to offer regular in-flight movies, 1961 | 53 |
| First Cartesian | 15 |
| First Catholic vice president of the U.S. | 41 |
| First celebrity on "Sesame Street" | 44 |
| First celebrity to use his likeness on a video game (albeit his was a primitive square) | 87 |
| First century Roman emperor | 27 |
| First cervical vertebra | 23 |
| First chair in the air | 22 |
| First chancellor of West Germany | 32 |
| First chapter in a primer | 25 |
| First character seen in "Zelig" | 41 |
| First character to appear in "Carmen" | 47 |
| First character to say "May the Force be with you" | 60 |
| First chief justice | 19 |
| First Chief Justice afoot? | 26 |
| First Chief Justice John | 24 |
| First Chief Justice of the United States | 40 |
| First child | 11 |
| First child of 1977-81 | 22 |
| First child, 1977-81 | 20 |
| First chimp to orbit Earth | 26 |
| First Chinese dynasty | 21 |
| First chip in | 13 |
| First chip thrown in | 20 |
| First chip tossed in | 20 |
| First chip, maybe | 17 |
| First chip, often | 17 |
| First chip, perhaps | 19 |
| First chips | 11 |
| First chips in the center | 25 |
| First chips in the middle | 25 |
| First chips in the pot | 22 |
| First choice | 12 |
| First choice, slangily | 22 |
| First choices | 13 |
| First Christian martyr | 22 |
| First Christmas travelers? | 26 |
| First Christmas visitors | 24 |
| First chronicled Chinese dynasty | 32 |
| First cigarette brand to introduce filters | 42 |
| First CinemaScope film | 22 |
| First CinemaScope film (With "The") | 45 |
| First CinemaScope movie | 23 |
| First circle of hell in Dante's "Inferno" | 55 |
| First circle on a Scantron sheet, often | 39 |
| First city bombed in W.W. II's Baedeker Blitz | 49 |
| First city of Brittany | 22 |
| First Civil War battle site | 27 |
| First claim, in slang | 21 |
| First claim, informally | 23 |
| First claim, slangily | 21 |
| First class | 11 |
| First class alternative | 23 |
| First class for painters | 24 |
| First class for some, briefly | 29 |
| First class, briefly, for some kids | 35 |
| First class, for short | 22 |
| First class, slangily | 21 |
| First class? | 12 |
| First cloned primate | 20 |
| First clothing | 14 |
| First club member | 17 |
| First clue | 10 |
| First clue in this puzzle | 25 |
| First coach, often | 18 |
| First coat | 10 |
| First coat of paint, sometimes | 30 |
| First code word | 15 |
| First coed college in U.S. | 26 |
| First college frat to charter a chapter in all 50 states | 56 |
| First colonial printer | 22 |
| First Colony V.I.P.'s | 25 |
| First column bingo call | 23 |
| First come-on | 13 |
| First comes love, then comes these three | 40 |
| First comes love, then comes these two | 38 |
| First comes love, then these four | 33 |
| First comes love, then these three | 34 |