| The Simpsons, e.g. | 18 |
| The sin bin | 11 |
| The sincerest of flattery | 25 |
| The Singh-ing golfer | 20 |
| The Singing Cowboy | 18 |
| The singing voice, informally | 29 |
| The single (hyph.) | 18 |
| The sinuses | 11 |
| The situation | 13 |
| The six days of the Creation | 28 |
| The six for a TD | 16 |
| The six of ''Little Nellie Kelly'' | 50 |
| The six of "Little Nellie Kelly" | 42 |
| The six-time champ | 18 |
| The Sixers play in it | 21 |
| The Sixth Amendment prevents trials in it, in most cases | 56 |
| The sixth of Henry VIII | 23 |
| The sixth sense | 15 |
| The Sixties, e.g. | 17 |
| The sixties, for one | 20 |
| The size of ___ (itty-bitty) | 28 |
| The Skagerrak, to the North Sea | 31 |
| The Skatalites' Jackie | 26 |
| The skeptic | 11 |
| The skin is one | 15 |
| The skin is the largest one in humans | 37 |
| The skinny | 10 |
| The Skins Game game | 19 |
| The Skins Game sport | 20 |
| The Skipper's plan, on paper | 32 |
| The skull reminded Hamlet that he ___ | 37 |
| The sky | 7 |
| The sky above Paris | 19 |
| The sky can be this | 19 |
| The sky is the ____ | 19 |
| The sky, at times | 17 |
| The sky, at times? | 18 |
| The sky, for some | 17 |
| The sky, it's said | 22 |
| The sky, maybe | 14 |
| The sky, perhaps | 16 |
| The sky, sometimes | 18 |
| The sky, to Atlas | 17 |
| The sky, to gamblers | 20 |
| The Skywalker boy, for short | 28 |
| The slam-dunker's violation? | 32 |
| The slammer | 11 |
| The slightest amount | 20 |
| The slightest amount, informally | 32 |
| The slightest bit | 17 |
| The slightest degree | 20 |
| The slightest number | 20 |
| The slightest peep | 18 |
| The slightest sound | 19 |
| The slim picture | 16 |
| The slim picture? | 17 |
| The slo-o-o-ow train | 20 |
| The slope of y = x + 2 | 22 |
| The slots | 9 |
| The slow lane | 13 |
| The slow lane's side | 24 |
| The slow way to go | 18 |
| The small dots on your dog after he's been sprayed? | 55 |
| The smallest | 12 |
| The smallest little bit | 23 |
| The smallest number divisible by the numbers 1 to 6 | 51 |
| The smallest of three famous ships | 34 |
| The smallest part | 17 |
| The smallest unit of DNA | 24 |
| The smart set | 13 |
| The smartest among us (var.) | 28 |
| The smartest Simpson kid | 24 |
| The Smashing Pumpkins' debut album, named for a silent film star | 68 |
| The smell of Geronimo? | 22 |
| The smile on a smiley face, say | 31 |
| The smile on an email happy face | 32 |
| The Smith's "How ___ Is Now?" | 43 |
| The Smith's "Louder ___ Bombs" | 44 |
| The Smiths guitarist Johnny | 27 |
| The Smiths singer, to fans | 26 |
| The Smiths' "Girlfriend in a ___" | 47 |
| The Smiths' dozer? | 22 |
| The Smiths' is self-titled | 30 |
| The Smithsonian, e.g. (Abbr.) | 29 |
| The Smithsonian, for ex. | 24 |
| The Smothers Brothers and others | 32 |
| The Smothers Brothers, e.g. | 27 |
| The Smothers Brothers, for one | 30 |
| The Snake borders it | 20 |
| The Snake flows along much of its border with Oregon | 52 |
| The Snake R. forms part of its border | 37 |
| The Snake R. runs through it | 28 |
| The Snake River snakes through it | 33 |
| The Snake snakes through it | 27 |
| The sneaker manufacturer started ... | 36 |
| The Sneetches' creator | 26 |
| The Snoopy ___-Cone Machine | 27 |
| The snowman was facing a ___ | 28 |
| The so-called "blue marble" | 37 |
| The so-called "dead man's hand," e.g. | 51 |