| Irksome swarm member | 20 |
| Irksome sort | 12 |
| Irksome response to "You're avoiding the question" | 64 |
| Irksome person | 14 |
| Irksome ones | 12 |
| Irksome one | 11 |
| Irksome individual | 18 |
| Irksome imps | 12 |
| Irksome fellow | 14 |
| Irksome | 7 |
| Irks some? | 10 |
| Irks greatly | 12 |
| Irks | 4 |
| Irking insect | 13 |
| Irked, with "off" | 27 |
| Irked with | 10 |
| Irked squared | 13 |
| Irked reaction | 14 |
| Irked a lot | 11 |
| Irked | 5 |
| Irk-aholic? | 11 |
| Irk, and then some | 18 |
| Irk to no end | 13 |
| Irk the man upstairs | 20 |
| Irk one's sweetheart? | 25 |
| Irk like crazy | 14 |
| Irk greatly | 11 |
| Irk | 3 |
| Irishmen | 8 |
| Irishman: Var. | 14 |
| Irishman, informally | 20 |
| Irishman, e.g. | 14 |
| Irishman's pride | 20 |
| Irishman's home goods store? | 32 |
| Irishman's expression of surprise | 37 |
| Irishman's darling | 22 |
| Irishman's dance | 20 |
| Irishman's activity on March 17 | 35 |
| Irishman who was a Time magazine Person of the Year in 2005 | 59 |
| Irishman or Welshman, e.g. | 26 |
| Irishman or Welshman | 20 |
| Irishman | 8 |
| Irish: Abbr. | 12 |
| Irish-themed Vegas casino that features a tattoo parlor owned by Mötley Crüe's Vince Neil | 99 |
| Irish-themed Vegas casino | 25 |
| Irish-stew ingredient | 21 |
| Irish-Sea isle | 14 |
| Irish-Gaelic | 12 |
| Irish-born Tony winner Patrick | 30 |
| Irish-born player John of Manchester United | 43 |
| Irish-born actress McKenna | 26 |
| Irish-born actor whose character in "Barbarella" inspired the band name Duran Duran | 93 |
| Irish-born actor Milo | 21 |
| Irish, for one | 14 |
| Irish, e.g. | 11 |
| Irish _____ Prince Edward Island special crop | 47 |
| Irish _____ | 11 |
| Irish ____ | 10 |
| Irish ___ | 9 |
| Irish __ | 8 |
| Irish writing | 13 |
| Irish writer-teacher | 20 |
| Irish writer who said "Always forgive your enemies; nothing annoys them so much" | 90 |
| Irish writer who coined the word "quark" | 50 |
| Irish writer O'Brien | 24 |
| Irish writer Edna | 17 |
| Irish writer Brendan | 20 |
| Irish writer Behan | 18 |
| Irish writer | 12 |
| Irish woodworker? | 17 |
| Irish woman patriot | 19 |
| Irish wit Oscar | 15 |
| Irish wit and playwright | 24 |
| Irish wit | 9 |
| Irish whisky | 12 |
| Irish whiskey brand | 19 |
| Irish weather forecast? | 23 |
| Irish wailer | 12 |
| Irish village | 13 |
| Irish version of John | 21 |
| Irish version of an old French coin? | 36 |
| Irish vagabonds | 15 |
| Irish V.I.P.'s | 18 |
| Irish tyranny? | 14 |
| Irish tune, when trilled in Turin? | 34 |
| Irish tribe | 11 |
| Irish town or county | 20 |
| Irish Tony winner Patrick | 25 |
| Irish tongue | 12 |
| Irish terriers, e.g. | 20 |
| Irish terrier, e.g. | 19 |
| Irish tenor Tynan | 17 |
| Irish tenor Ronan | 17 |
| Irish tax | 9 |
| Irish symbol | 12 |
| Irish sweetheart | 16 |
| Irish Sweepstakes figures | 25 |
| Irish sweater worn by fishermen | 31 |
| Irish surname starter | 21 |
| Irish stew tidbit | 17 |