| Highly volatile gas, for short | 30 |
| Highly volatile fuel: Abbr. | 27 |
| Highly vigilant | 15 |
| Highly venomous stinger | 23 |
| Highly venomous snakes | 22 |
| Highly venomous snake | 21 |
| Highly veined, as flies' wings | 34 |
| Highly valued land, say | 23 |
| Highly valued fertilizer | 24 |
| Highly valued asset, and this puzzle's title | 48 |
| Highly valued | 13 |
| Highly unusual event | 20 |
| Highly unusual | 14 |
| Highly unskilled servers? | 25 |
| Highly unlikely, as chances | 27 |
| Highly unlikely, as a chance | 28 |
| Highly unlikely to change | 25 |
| Highly unconventional | 21 |
| Highly uncommon | 15 |
| Highly uncertain | 16 |
| Highly toxic pollutants | 23 |
| Highly toxic environmental pollutants, for short | 48 |
| Highly timely | 13 |
| Highly thought of | 17 |
| Highly successful, in Varietyese | 32 |
| Highly successful reviews | 25 |
| Highly successful Hollywood actor James presently on "General Hospital" | 81 |
| Highly successful | 17 |
| Highly stylized sculpting style | 31 |
| Highly structured echoic poems | 30 |
| Highly structured 39-line poem | 30 |
| Highly spiced stew | 18 |
| Highly spiced smoked beef | 25 |
| Highly spiced dish | 18 |
| Highly spiced | 13 |
| Highly speculative | 18 |
| Highly specific specialties | 27 |
| Highly sought-after item | 24 |
| Highly sought-after grocery item | 32 |
| Highly sought-after | 19 |
| Highly sought statue | 20 |
| Highly sought shares | 20 |
| Highly sought after | 19 |
| Highly sloped | 13 |
| Highly skilled workers | 22 |
| Highly skilled worker | 21 |
| Highly skilled people | 21 |
| Highly skilled ones | 19 |
| Highly skilled one | 18 |
| Highly skilled musician | 23 |
| Highly skilled in | 17 |
| Highly skilled | 14 |
| Highly significant | 18 |
| Highly sharpened | 16 |
| Highly sensitive | 16 |
| Highly self-satisfied | 21 |
| Highly seismic area off the Greek coast | 39 |
| Highly seasoned white sauce | 27 |
| Highly seasoned stews | 21 |
| Highly seasoned stew | 20 |
| Highly seasoned sausage | 23 |
| Highly seasoned ragout | 22 |
| Highly seasoned pheasant stew | 29 |
| Highly seasoned meat dish | 25 |
| Highly seasoned fowl dish | 25 |
| Highly seasoned dishes | 22 |
| Highly seasoned dish | 20 |
| Highly seasoned | 15 |
| Highly rhetorical shouts for attention? | 39 |
| Highly revered one | 18 |
| Highly respected | 16 |
| Highly resonant Indian drums | 28 |
| Highly remarkable | 17 |
| Highly religious Jew | 20 |
| Highly reliable evidence | 24 |
| Highly regards | 14 |
| Highly regarded, so to speak | 28 |
| Highly regarded, slangily | 25 |
| Highly regarded, militarily | 27 |
| Highly regarded groups | 22 |
| Highly regarded group | 21 |
| Highly regarded | 15 |
| Highly regard | 13 |
| Highly reflective finish | 24 |
| Highly reflective | 17 |
| Highly recommends | 17 |
| Highly recommended show | 23 |
| Highly recommended film | 23 |
| Highly recommended book | 23 |
| Highly recommend? | 17 |
| Highly recommend | 16 |
| Highly reactive metal | 21 |
| Highly rated security | 21 |
| Highly rated individuals? | 25 |
| Highly rated court figure | 25 |
| Highly rated 1997 film with the song "Tupelo Honey" | 61 |
| Highly rated | 12 |
| Highly ranked noblemen | 22 |
| Highly qualified for a job | 26 |
| Highly proper | 13 |