| Swiss mathematician for whom a lunar crater was named | 53 |
| Swiss surrealist who did set design on “Alien” | 54 |
| Swiss watch brand sported since '95 by film's James Bond | 64 |
| Swiss watch that's the official timekeeper of the French Open | 65 |
| Swordsman's belt worn diagonally from shoulder to hip | 57 |
| Sykes of "The New Adventures of Old Christine" | 56 |
| Syllable before "boom" in a classic Crew-Cuts song | 60 |
| Syllable on a Valentine's Day card from Ralph Wiggum | 56 |
| Syllables before "Di" and "Da" in a Beatles song | 68 |
| Syllables before "di" or "da" in a Beatles song | 67 |
| Syllables before "Di" or "Da" in a Beatles title | 68 |
| Syllables following "Strike the harp and join the chorus" | 67 |
| Syllables sometimes said with one's fingers in one's ears | 65 |
| Sylph in Pope's "The Rape of the Lock" | 52 |
| Sylvia who played the Queen Mother in "The Queen" | 59 |
| Sylvia's mom in the comic strip "Pickles" | 55 |
| Symbol in computing that indicates moving one unit to the left | 62 |
| Symbol of absence to whom "Waiting for Guffman" refers | 64 |
| Symbol of rejoicing for someone's long-awaited return | 57 |
| Symbol of Scotland on the United Kingdom Royal Coat of Arms | 59 |
| Symbol of St. Barnabas, whose saint day comes at hay harvesting time | 68 |
| Symbol on the Broadway poster of "Beauty and the Beast" | 65 |
| Symbols marking spurious passages in old manuscripts | 52 |
| Symphonic '70s rockers named after Camelot lady? | 52 |
| Symphony on Norman Bates's phonograph in "Psycho" | 63 |
| Symptom of one's waxing starting to grow out, maybe | 55 |
| Syndicated show offering "life strategies" | 52 |
| Syndrome that some parents experience when children leave home | 62 |
| Synonym for "Pavarottis," in British money slang | 58 |
| Synonym for the first words of this puzzle's four longest answers | 69 |
| Synonym for this puzzle's title hiding in four places | 57 |
| Synthetic fiber used in bicycle tires and bulletproof vests | 59 |
| System of a Down song off "Steal This Album!" | 55 |
| System that helps you determine if someone's your type | 58 |
| System where "187" means "homicide" | 55 |
| System wherein "Gentlemen" looks like a "U" | 63 |