| Isaac of music | 14 |
| Isaac of fiddledom | 18 |
| Isaac Newton, e.g. | 18 |
| Isaac Newton's inspiration | 30 |
| Isaac Hayes soundtrack | 22 |
| Isaac Hayes did its theme song | 30 |
| Isaac Caesar's stage name | 29 |
| Isaac Brock's "Casanova" | 38 |
| Isaac Brock side project ___ Casanova | 37 |
| Isaac Bickerstaff was one of his pen names | 42 |
| Isaac Bickerstaff | 17 |
| Isaac Bashevis Singer's language | 36 |
| Isaac Bashevis Singer's "Yeshiva Boy" | 51 |
| Isaac Bashevis Singer story "___ the Yeshiva Boy" | 59 |
| Isaac Bashevis Singer settings | 30 |
| Isaac Bashevis Singer novel | 27 |
| Isaac Bashevis Singer character | 31 |
| Isaac Asimov, notably | 21 |
| Isaac Asimov's genre | 24 |
| Isaac Asimov's birthplace | 29 |
| Isaac Asimov's "Murder at the ___" | 48 |
| Isaac Asimov wore them | 22 |
| Isaac Asimov wore one | 21 |
| Isaac Asimov novel | 18 |
| Isaac Asimov mystery "Murder at the ___" | 50 |
| Isaac Asimov classic | 20 |
| Isaac Asimov character | 22 |
| Isaac Asimov book made into a 2004 Will Smith film | 50 |
| Isaac and Rebekah's firstborn | 33 |
| Isaac and Rebekah's eldest | 30 |
| Isaac and Howard | 16 |
| Isaac and Eisenhower | 20 |
| Isaac Alb niz composition | 25 |
| Isaac | 5 |
| Is: Lat. | 8 |
| Is: Fr. | 7 |
| Is, when simplified | 19 |
| Is, to Isabella | 15 |
| Is, pluralized | 14 |
| Is, on Ibiza | 12 |
| Is, in math | 11 |
| Is, in Ixtapa | 13 |
| Is, in Isère | 15 |
| Is, in Ibiza | 12 |
| Is, in Iberville | 16 |
| Is, in history? | 15 |
| Is, for Ovid | 12 |
| Is, for more than one | 21 |
| Is, for many | 12 |
| Is ___ unto oneself | 19 |
| Is ___ promise? | 15 |
| Is ___ bird? | 12 |
| Is ___ (probably will) | 22 |
| Is __: probably will | 20 |
| Is __: likely will | 18 |
| Is __ (probably will) | 21 |
| Is zetetic | 10 |
| Is wrong | 8 |
| Is worthy of, as repeating | 26 |
| Is worthy of | 12 |
| Is worthy | 9 |
| Is worthwhile | 13 |
| Is worth something, colloquially | 32 |
| Is worth it | 11 |
| Is worth doing | 14 |
| Is worth | 8 |
| Is worse than ever | 18 |
| Is worried about | 16 |
| Is without | 10 |
| Is within earshot | 17 |
| Is with you | 11 |
| Is wistful (for) | 16 |
| Is wiped out | 12 |
| Is willingly up to no good | 26 |
| Is willing to | 13 |
| Is wildly unstable | 18 |
| Is wild about | 13 |
| Is wide open, as a chasm | 24 |
| Is well-versed in a subject | 27 |
| Is well-informed | 16 |
| Is well-endowed? | 16 |
| Is well suited to be a reporter | 31 |
| Is weary | 8 |
| Is wearisome due to excess | 26 |
| Is wearisome | 12 |
| Is wearing | 10 |
| Is way off base | 15 |
| Is way cool | 11 |
| Is wavering | 11 |
| Is watchful | 11 |
| Is wanting | 10 |
| Is wafted on the breeze | 23 |
| Is visibly miserable | 20 |
| Is visibly frightened | 21 |
| Is visibly elated | 17 |
| Is vigilant | 11 |
| Is victorious over | 18 |
| Is victorious | 13 |
| Is vexing | 9 |
| Is very wary of | 15 |