| Second emissary | 15 |
| Second emperor after Nero | 25 |
| Second ending | 13 |
| Second ending? | 14 |
| Second Estate | 13 |
| Second excuse | 13 |
| Second family of the 1990's | 31 |
| Second fiddle | 13 |
| Second film in a 2000s horror franchise | 39 |
| Second film in a sci-fi series | 30 |
| Second film shot | 16 |
| Second finisher? | 16 |
| Second first lady | 17 |
| Second flip | 11 |
| Second floor of a home, say | 27 |
| Second follower | 15 |
| Second from the flock | 21 |
| Second fruit eater | 18 |
| Second game show host in the Canada's Walk of Fame | 54 |
| Second generation Japanese-American | 35 |
| Second generation member | 24 |
| Second glassful | 15 |
| Second glove | 12 |
| Second go-around | 16 |
| Second go-rounds | 16 |
| Second Gospel | 13 |
| Second Gospel writer | 20 |
| Second governor of New York | 27 |
| Second Greek consonant | 22 |
| Second Greek letter | 19 |
| Second greeting | 15 |
| Second group in a voice vote | 28 |
| Second guessed | 14 |
| Second H.S. squad | 17 |
| Second half of a ball game? | 27 |
| Second half of a cassette | 25 |
| Second half of a cocktail | 25 |
| Second half of a court game | 27 |
| Second half of a doubleheader | 29 |
| Second half of a game | 21 |
| Second half of a jaded response | 31 |
| Second half of a mountaineer's trip | 39 |
| Second half of a musical | 24 |
| Second half of a record | 23 |
| Second half of a rhyming Beatles title | 38 |
| Second half of a ring | 21 |
| Second half of a TV show? | 25 |
| Second half of a vote | 21 |
| Second half of an album | 23 |
| Second half of an audiotape | 27 |
| Second half of an exploring duo | 31 |
| Second half of an inning | 24 |
| Second half of CLUE #2 | 22 |
| Second half of many annoyingly overenthusiastic portmanteaus | 60 |
| Second half of quote | 20 |
| Second half of the quote | 24 |
| Second half of things we all memorized | 38 |
| Second hand | 11 |
| Second hand: Abbr. | 18 |
| Second hand? | 12 |
| Second hands: Abbr. | 19 |
| Second hearing? | 15 |
| Second Hebrew letters | 21 |
| Second helping | 14 |
| Second helping, e.g. | 20 |
| Second helping, to a dieter | 27 |
| Second highest in a family of instruments | 41 |
| Second highest peak in N.A. | 27 |
| Second highest pinochle card | 28 |
| Second highest, in a family of instruments | 42 |
| Second home of a sort | 21 |
| Second homes for apparatchiks | 29 |
| Second human on the moon | 24 |
| Second impression? | 18 |
| Second in a certain series | 26 |
| Second in a classic Latin trio | 30 |
| Second in a classical trio | 26 |
| Second in a German series | 25 |
| Second in a Greek series | 24 |
| Second in a Latin series | 24 |
| Second in a series | 18 |
| Second in a series of sharp turns | 33 |
| Second in a series of Web postings | 34 |
| Second in a Sue Grafton series | 30 |
| Second in all-time hits | 23 |
| Second in cmd. | 14 |
| Second in command | 17 |
| Second in command in the state: Abbr. | 37 |
| Second in command, briefly | 26 |
| Second in command, informally | 29 |
| Second in command, maybe | 24 |
| Second in command, often | 24 |
| Second in command: abbr. | 24 |
| Second in command? | 18 |
| Second in court?: Abbr. | 23 |
| Second in crime | 15 |
| Second in evildoing | 19 |
| Second in line? | 15 |
| Second in order | 15 |
| Second in the credits, often | 28 |