| Space Race participant | 22 |
| Space saucers, briefly | 22 |
| Space shuttle component | 23 |
| Space shuttle launcher | 22 |
| Space shuttle protector | 23 |
| Space shuttle's org. | 24 |
| Space shuttle's path | 24 |
| Space station from 1973-79 | 26 |
| Space station until 2001 | 24 |
| Space station with cosmonauts | 29 |
| Space studier's field | 25 |
| Space travel phenomenon | 23 |
| Space traveler of 1957 | 22 |
| Space traveler of serials | 25 |
| Space traveler's booking? | 29 |
| Space travelers' garments | 29 |
| Space visitors, briefly | 23 |
| Space walks, for short | 22 |
| Space where programmers work? | 29 |
| Space writer Willy and others | 29 |
| Space-age affirmatives | 22 |
| Space-age bachelor pad type | 27 |
| Space-based navig. tool | 23 |
| Space-exploration org. | 22 |
| Space-going chimp of 1961 | 25 |
| Space-race participant | 22 |
| Space-saver for data filing | 27 |
| Space-saver for writers | 23 |
| Space-saver in a studio | 23 |
| Space-saver on a subway | 23 |
| Space-saving abbreviation | 25 |
| Space-saving computer monitor | 29 |
| Space-saving library medium | 27 |
| Space-saving list ender | 23 |
| Space-saving spare tire | 23 |
| Space-saving term in endnotes | 29 |
| Space-saving, in a way | 22 |
| Space-shuttle's path | 24 |
| Space-vehicle boosters | 22 |
| Spacecraft "brake" | 28 |
| Spacecraft compartment | 22 |
| Spacecraft compartments | 23 |
| Spacecraft designer ___ Musk | 28 |
| Spacecraft from far away | 24 |
| Spacecraft letters, once | 24 |
| Spacecraft orbiting Mars | 24 |
| Spacecraft part, for short | 26 |
| Spacecraft rocket, for short | 28 |
| Spacecraft sent toward Mars | 27 |
| Spacecrafts' goods | 22 |
| Spaced-out Houston agcy.? | 25 |
| Spaceflight award won in 2004 | 29 |
| Spaceflight management center | 29 |
| Spacehog "Resident" | 29 |
| Spacehog's 1st album | 24 |
| Spacek of 'Carrie' | 26 |
| Spacek of "Carrie" | 28 |
| Spacek's biopic role | 24 |
| Spacek's Oscar role | 23 |
| Spaceman hero in comics | 23 |
| Spacemate of Michael and Buzz | 29 |
| Spaces between leaf veins | 25 |
| Spaces left by lumberjacks | 26 |
| Spaces on birds' faces | 26 |
| Spaces used by typographers | 27 |
| Spaceship Earth is its icon | 27 |
| Spaceship Earth is there | 24 |
| Spaceship Earth locale | 22 |
| Spaceship Earth setting | 23 |
| Spaceship supply, once | 22 |
| Spaceship's home stretch | 28 |
| Spacewalk, acronymically | 24 |
| Spacewalk, e.g.: Abbr. | 22 |
| Spacewalks, in NASA-speak | 25 |
| Spacey role in a 2004 biopic | 28 |
| Spacey Teenage Fanclub song? | 28 |
| Spacious accommodations | 23 |
| Spacious building areas | 23 |
| Spacious hotel offerings | 24 |
| Spacious hotel reservation | 26 |
| Spacious, as a kitchen | 22 |
| Spacious, to Stéphane | 24 |
| Spade player, familiarly | 24 |
| Spade that digs up dirt | 23 |
| Spade, e.g., for short | 22 |
| Spade-shaped reef swimmer | 25 |
| Spades, but not shovels | 23 |
| Spaghetti accompaniment | 23 |
| Spaghetti and macaroni | 22 |
| Spaghetti and vermicelli | 24 |
| Spaghetti recipe phrase | 23 |
| Spaghetti sauce flavoring | 25 |
| Spaghetti sauce ingredient | 26 |
| Spaghetti sauce ingredients | 27 |
| Spaghetti sauce seasoning | 25 |
| Spaghetti sauce slogan | 22 |
| Spaghetti sauce topper | 22 |
| Spaghetti seasoning: abbr. | 26 |
| Spaghetti specification | 23 |
| Spaghetti topper, perhaps | 25 |