| What can be a turnoff? | 22 |
| What can be edited with the Avogadro app | 40 |
| What can be said about the answers to this puzzle's capitalized clues | 73 |
| What can escape from a black hole | 33 |
| What can get you down? | 22 |
| What can give you a heads-up? | 29 |
| What can hang unpleasantly over a city | 38 |
| What can help you toward a peak performance? | 44 |
| What can one do? | 16 |
| What can open files? | 20 |
| What can open laterally? | 24 |
| What can produce a "boing!"? | 38 |
| What can take your breath away in L.A.? | 39 |
| What can turn one into many? | 28 |
| What can't be parted after it's departed? | 49 |
| What candidates hit | 19 |
| What candidates stand on? | 25 |
| What candles at a party signify | 31 |
| What candles may represent | 26 |
| What candles may reveal | 23 |
| What candles may signify | 24 |
| What candles on a cake might indicate | 37 |
| What candles sometimes represent | 32 |
| What candles sometimes reveal | 29 |
| What candy satisfies | 20 |
| What canoe is to ocean | 22 |
| What Capote called Henry James | 30 |
| What Captain Kirk kept | 22 |
| What captains and kings do | 26 |
| What carats measure | 19 |
| What carbon dioxide reacts with to form carbonic acid | 53 |
| What carbon monoxide lacks | 26 |
| What career finally did | 23 |
| What caring people give | 23 |
| What Carlin and Brenner do | 26 |
| What carnivores eat | 19 |
| What carnivores like to do after a hard day at the office? | 58 |
| What Carole King hummed as she missed her plane? | 48 |
| What carolers do | 16 |
| What carpenters do on Labor Day? | 32 |
| What Carroll's walrus did | 29 |
| What Carroll's walrus did it | 32 |
| What Carry Nation carried | 25 |
| What Carson and Leno do | 23 |
| What Casey didn't get | 25 |
| What casinos advertise | 22 |
| What Casper tries not to do | 27 |
| What Cassius Clay said starting in 1964? | 40 |
| What Cassius lacked | 19 |
| What cast members fill | 22 |
| What Castro calls home? | 23 |
| What casts do | 13 |
| What cat burglars do? | 21 |
| What catchers do | 16 |
| What catchy song does | 21 |
| What catnip is to a cat | 23 |
| What cats and bats do | 21 |
| What cats and rats do | 21 |
| What cats and waves do | 22 |
| What cats are prone to do | 25 |
| What cats do ... or sit on | 26 |
| What cats often do in the spring | 32 |
| What causes Fred to be fired? | 29 |
| What César awards honor | 26 |
| What CBers watch for | 20 |
| What CD players don't require | 33 |
| What celebrants kick up | 23 |
| What celebrators make | 21 |
| What century plants do only once | 32 |
| What certain braggarts eat | 26 |
| What certain guards do well | 27 |
| What certain jets avoid | 23 |
| What certain pads protect | 25 |
| What certain rioting Elizabethan musicians did? | 47 |
| What Ceylon, Siam and Upper Volta are nowadays? | 47 |
| What CFC's deplete | 22 |
| What chambers of commerce do, and this puzzle's title | 57 |
| What champions never say | 24 |
| What Chang and Eng could never be | 33 |
| What changes a drum to a male cat? | 34 |
| What changing the f-stop changes | 32 |
| What Chanticleer rules | 22 |
| What chaperones may count | 25 |
| What charcoal does | 18 |
| What charcoal does to gases | 27 |
| What charities hope for | 23 |
| What Charlie Brown calls his teacher | 36 |
| What Charlie Brown says when he's mad | 41 |
| What Charlie likes to have? | 27 |
| What Charlie rides, in a 1959 hit | 33 |
| What Chaucer's pilgrims do | 30 |
| What cheaters exhibit | 21 |
| What cheats may do | 18 |
| What cheerleaders clean their equipment with | 44 |
| What cheerleaders do | 20 |
| What cheerleaders elicit | 24 |
| What cheerleaders have in a pouring rain? | 41 |
| What cheese has that pâté doesn't? | 44 |
| What cheesy pop music lacks | 27 |
| What Cheever called "the triumph over chaos" | 54 |