| Desolate, once | 14 |
| Desolate, to the Bard | 21 |
| Desolated | 9 |
| Desolation | 10 |
| DeSoto alternatives | 19 |
| DeSoto contemporary | 19 |
| DeSoto or Hudson | 16 |
| DeSoto or LaSalle | 17 |
| DeSoto, e.g. | 12 |
| DeSoto, Hudson, or LaSalle | 26 |
| Despair | 7 |
| Despair locale | 14 |
| Despair's opposite | 22 |
| Despairing | 10 |
| Despairing sound | 16 |
| Despairing utterance | 20 |
| Despairs | 8 |
| Desperado | 9 |
| Desperado chaser | 16 |
| Desperado chasers | 17 |
| Desperado doggers | 17 |
| Desperado hunters | 17 |
| Desperado of the 19th century | 29 |
| Desperado's weapon | 22 |
| Desperados | 10 |
| Desperate | 9 |
| Desperate attempt to end a drought | 34 |
| Desperate attempt to influence an election | 42 |
| Desperate battlefield cry | 25 |
| Desperate bet | 13 |
| Desperate cake-ophile's attitude? | 37 |
| Desperate call | 14 |
| Desperate call, for short | 25 |
| Desperate cry | 13 |
| Desperate dash | 14 |
| Desperate dieter's stricken facial expression? | 50 |
| Desperate farmer's transaction? | 35 |
| Desperate final effort | 22 |
| Desperate for change | 20 |
| Desperate guess | 15 |
| Desperate hope | 14 |
| Desperate housewife Hatcher | 27 |
| Desperate initials | 18 |
| Desperate letters | 17 |
| Desperate measures | 18 |
| Desperate measures during a shortage | 36 |
| Desperate need of Richard III | 29 |
| Desperate plea | 14 |
| Desperate politician during a campaign, perhaps | 47 |
| Desperate signal | 16 |
| Desperate steps | 15 |
| Desperate strategy | 18 |
| Desperate to try a prison break, say | 36 |
| Desperate trio | 14 |
| Desperate try | 13 |
| Desperate TV character? | 23 |
| Desperate way to run | 20 |
| Desperate, as a situation | 25 |
| Desperate, as a warning | 23 |
| Desperate, as an effort | 23 |
| Desperate, as circumstances | 27 |
| Desperate, as straits | 21 |
| Desperately | 11 |
| Desperately dry | 15 |
| Desperately hanging on | 22 |
| Desperately longing (to) | 24 |
| Desperately needed a shower | 27 |
| Desperately needing a map | 25 |
| Desperately needing rain | 24 |
| Desperately tries to get | 24 |
| Desperately urgent | 18 |
| Desperately want | 16 |
| Desperation equipment | 21 |
| Desperation football pass | 25 |
| Desperation gridiron pass | 25 |
| Desperation guess | 17 |
| Desperation tactic | 18 |
| Desperation, of a sort | 22 |
| Despereaux, for one | 19 |
| Despicable | 10 |
| Despicable character | 20 |
| Despicable fellow | 17 |
| Despicable one | 14 |
| Despicable ones | 15 |
| Despicable people | 17 |
| Despicable person | 17 |
| Despicable person, in slang | 27 |
| Despicable persons | 18 |
| Despicable slimeball | 20 |
| Despicable sort | 15 |
| Despicable sorts | 16 |
| Despicable thief? | 17 |
| Despicable to the nth degree | 28 |
| Despicably cowardly dentist? | 28 |
| Despina, in "Cosi fan tutte" | 38 |
| Despise | 7 |
| Despise deeply | 14 |
| Despise the hell out of | 23 |
| Despise with a passion | 22 |
| Despised | 8 |