| Substantial entrees | 19 |
| Substantial content | 19 |
| Substantial bodies of work | 26 |
| Substantial bit | 15 |
| Substantial bill | 16 |
| Substantial baby shower gift | 28 |
| Substantial amounts | 19 |
| Substantial | 11 |
| Substandard marks | 17 |
| Substandard language form | 25 |
| Substandard item | 16 |
| Substandard grade | 17 |
| Substandard effort | 18 |
| Substandard contraction | 23 |
| Substandard | 11 |
| Substances with low pH | 22 |
| Substances used in soap | 23 |
| Substances used in chemical analysis | 36 |
| Substances used by etchers | 26 |
| Substances that ooze out | 24 |
| Substances that make paint set more quickly | 43 |
| Substances similar in structure, in chemistry | 45 |
| Substances sans liquid or gas | 29 |
| Substances like water, vis-Ã -vis sugar | 41 |
| Substances in seams | 19 |
| Substances for Strads | 21 |
| Substances essential, in minute quantities, to nutrition | 56 |
| Substances derived from nitrogen | 32 |
| Substances collectively called "the bad cholesterol" | 62 |
| Substance-banning agcy. | 23 |
| Substance-abusing star of "Mean Girls" in headlines | 61 |
| Substance, such as benzene | 26 |
| Substance's partner | 23 |
| Substance written about in Jose Canseco's "Juiced" | 64 |
| Substance with a pH higher than 7 | 33 |
| Substance with a low pH | 23 |
| Substance with a historical museum in Amsterdam | 47 |
| Substance whose synthesis required a "life force," alchemists believed | 80 |
| Substance usually abbreviated | 29 |
| Substance used to protect or stabilize | 38 |
| Substance used to make ink | 26 |
| Substance used to ignite firework fuses | 39 |
| Substance used to curdle milk | 29 |
| Substance used in treating acne | 31 |
| Substance used in perfumes | 26 |
| Substance used in immunology | 28 |
| Substance used in fillings? | 27 |
| Substance used in chemical analysis | 35 |
| Substance used in an old punishment | 35 |
| Substance used in adhesives and paints | 38 |
| Substance used for polishing | 28 |
| Substance used for moldings | 27 |
| Substance used by whales as a feeding filter | 44 |
| Substance used by watchmakers | 29 |
| Substance used by some in baseball's Mitchell Report | 56 |
| Substance used by dyers | 23 |
| Substance used as an antioxidant, in some alternative medicines | 63 |
| Substance under Little Cat Z's hat in "The Cat in the Hat Comes Back" | 83 |
| Substance that undergoes a chemical change | 42 |
| Substance that may darken your pasta | 36 |
| Substance that may be donated | 29 |
| Substance that makes you hot | 28 |
| Substance that gives red wine bite | 34 |
| Substance that colors | 21 |
| Substance that citrus peels are rich in | 39 |
| Substance taken up in a lab | 27 |
| Substance susceptibility | 24 |
| Substance stimulating antibody production | 41 |
| Substance scraped by a Zamboni | 30 |
| Substance resembling dentin | 27 |
| Substance put on wounds | 23 |
| Substance partner | 17 |
| Substance overdoer | 18 |
| Substance on some mountains or in some lamps | 44 |
| Substance on an envelope | 24 |
| Substance of some crowns | 24 |
| Substance of interest to the CIA in the 1950s | 45 |
| Substance of genetic importance | 31 |
| Substance of a newspaper article? | 33 |
| Substance of a 1963 treaty | 26 |
| Substance obtained from wool | 28 |
| Substance obtained from some pines | 34 |
| Substance marketed under the name NutraSweet | 44 |
| Substance in wheat flour | 24 |
| Substance in the sea's H2O | 30 |
| Substance in the Nash poem "Reflection on Babies" | 59 |
| Substance in the Baseball Hall of Fame debate | 45 |
| Substance in Spandex | 20 |
| Substance in some signs | 23 |
| Substance in some piecrusts | 27 |
| Substance in some lamps | 23 |
| Substance in some cough syrups | 30 |
| Substance in soaps | 18 |
| Substance in skin care | 22 |
| Substance in salad dressing | 27 |
| Substance in red wine | 21 |
| Substance in cigarettes | 23 |
| Substance in chemical analysis | 30 |
| Substance in cereals | 20 |
| Substance in an oyster | 22 |