| U.S. columnist | 14 |
| U.S. colony, symbolically | 25 |
| U.S. college member | 19 |
| U.S. collection agcy. | 21 |
| U.S. coin, 1916-45 | 18 |
| U.S. coin word | 14 |
| U.S. coin motto starter | 23 |
| U.S. code and cipher grp. | 25 |
| U.S. Coast Guard woman | 22 |
| U.S. clergyman-author: 1663-1728 | 32 |
| U.S. clergyman | 14 |
| U.S. claim-settling dept. | 25 |
| U.S. Civil War starting point | 29 |
| U.S. civil rights promoter | 26 |
| U.S. city, for short | 20 |
| U.S. city with tons of expensive bars | 37 |
| U.S. city whose name is pronounced differently from its foreign namesake | 72 |
| U.S. city that's almost as large in area as Delaware | 56 |
| U.S. city that's a girl's name | 38 |
| U.S. city or river | 18 |
| U.S. city near Russia | 21 |
| U.S. city named for a Tennyson character | 40 |
| U.S. city known to some locals as Siqnazuaq | 43 |
| U.S. city in sight of two volcanoes | 35 |
| U.S. city | 9 |
| U.S. citizen: Abbr. | 19 |
| U.S. citizen-to-be | 18 |
| U.S. citizen, e.g. | 18 |
| U.S. citizen's nine digits | 30 |
| U.S. citizen since 1845 | 23 |
| U.S. citizen living near the Panama Canal, once | 47 |
| U.S. citizen | 12 |
| U.S. cit. | 9 |
| U.S. chief justice, 1953-69 | 27 |
| U.S. Chief Justice, 1936-65 | 27 |
| U.S. chief justice 1836-64 | 27 |
| U.S. chemist who discovered deuterium | 37 |
| U.S. chain-store pioneer | 24 |
| U.S. chain stores since 1985 | 28 |
| U.S. central bank system, with "the" | 46 |
| U.S. Cellular Field team | 24 |
| U.S. Cellular Field boyfriend? | 30 |
| U.S. cartoonist: 1840–1902 | 33 |
| U.S. cartoonist | 15 |
| U.S. carrier | 12 |
| U.S. caricaturist's family | 30 |
| U.S. caricaturist | 17 |
| U.S. cardinal | 13 |
| U.S. Capitol's vicinity | 27 |
| U.S. Capitol Building area | 26 |
| U.S. capitalist | 15 |
| U.S. capital? | 13 |
| U.S. capital, 1789-90 | 21 |
| U.S. capital, 1785-90 | 21 |
| U.S. capital whose last two letters are its state | 49 |
| U.S. capital nearest the Arctic Circle | 38 |
| U.S. capital and environs | 25 |
| U.S. capital | 12 |
| U.S. canal | 10 |
| U.S. cabinet that decides wage standards, for short | 51 |
| U.S. Cabinet post | 17 |
| U.S. Cabinet divisions | 22 |
| U.S. cabinet dept. | 18 |
| U.S. Cabinet department | 23 |
| U.S. Cab. post | 14 |
| U.S. C. : Pac 10 :: Duke : ___ | 30 |
| U.S. C-in-C | 11 |
| U.S. business treaty | 20 |
| U.S. business economist | 23 |
| U.S. bureaucracy | 16 |
| U.S. bureau | 11 |
| U.S. bullion site | 17 |
| U.S. budget outlay | 18 |
| U.S. broadcaster overseas: Abbr. | 32 |
| U.S. broadcaster overseas | 25 |
| U.S. broadcaster in 40+ languages | 33 |
| U.S. Brig Niagara's port | 28 |
| U.S. brand retired in 1972 | 26 |
| U.S. botanist Gray | 18 |
| U.S. botanist | 13 |
| U.S. border lake | 16 |
| U.S. bond market purchase | 25 |
| U.S. bombs | 10 |
| U.S. bird | 9 |
| U.S. biomedical research agcy. | 30 |
| U.S. bill | 9 |
| U.S. beverage since 1923 | 24 |
| U.S. beef center | 16 |
| U.S. beasts | 11 |
| U.S. battleship: 1898 | 21 |
| U.S. base in Cuba, informally | 29 |
| U.S. base in Cuba, in headlines | 31 |
| U.S. base in Cuba, briefly | 26 |
| U.S. banking system, with “the” | 39 |
| U.S. banking family | 19 |
| U.S. banker-philanthropist: 1867-1933 | 37 |
| U.S. banker | 11 |
| U.S. bank regulator | 19 |
| U.S. bank established in 1934, informally | 41 |
| U.S. balloon pioneer | 20 |