| Only pitcher of two consecutive no-hitters Johnny Vander ___ | 60 |
| Only person whose son and brother also won the Indianapolis 500 | 63 |
| Only person to win two Nobels in two different sciences | 55 |
| Only person to win Oscars for acting and screenwriting | 54 |
| Only person to win Emmys for acting, writing and directing | 58 |
| Only person to win both an Oscar and a Nobel | 44 |
| Only person to win an Oscar and a Razzie for Direction (not for the same movie, however) | 88 |
| Only person to have the #1 movie, #1 album and #1-rated late-night TV show all in the same week | 95 |
| Only person to guest-host "The Tonight Show With Jay Leno" | 68 |
| Only person to garner Oscar nominations for producer, director, writer, and actor for two films | 95 |
| Only person to decline the Nobel Peace Prize | 44 |
| Only performer to appear in every episode of "Knots Landing" | 70 |
| Only perfect World Series pitcher | 33 |
| Only patron on "Cheers" to appear in all 275 episodes | 63 |
| Only partner? | 13 |
| Only partner | 12 |
| Only partly | 11 |
| Only part of Egypt in Asia | 26 |
| Only Pacific island monarchy | 28 |
| Only Pacific Division NBA team not based in California | 54 |
| Only outfielder besides Winfield to win Gold Gloves in both leagues in the 1900s | 80 |
| Only other state in Alaska's time zone | 42 |
| Only openings for air? | 22 |
| Only one-word anagram of a day of the week | 42 |
| Only one-syllable state name | 28 |
| Only one-syllable state | 23 |
| Only one U.S. prez has had one | 30 |
| Only one of their members was actually born in Australia | 56 |
| Only one of the Seven Dwarfs to wear glasses | 44 |
| Only one of the 13 Colonies not touching the Atl. Ocean | 55 |
| Only one bears the name of a U.S. president | 43 |
| Only once in a while | 20 |
| Only okay | 9 |
| Only OK | 7 |
| Only occupant of Vostok I | 25 |
| Only O.T. book that never mentions God: Abbr. | 45 |
| Only O.K. | 9 |
| Only now and then | 17 |
| Only Norwegian band to do a James Bond theme song | 49 |
| Only nonvocal instrument in Britten's "Ceremony of Carols" | 72 |
| Only nonsentient zodiac symbol | 30 |
| Only nonrhyming ghost in Ms. Pac-Man | 36 |
| Only non-U.S. M.L.B. team: Abbr. | 32 |
| Only non-U.S. M.L.B. team, on scoreboards | 41 |
| Only non-Southern state won by the G.O.P. in '64 | 57 |
| Only non-actor ever chosen as People's Sexiest Man Alive, familiarly | 72 |
| Only NL team never to have played in the World Series, briefly | 62 |
| Only NFL coach to have a perfect season | 39 |
| Only NFC team to never to play in the Super Bowl | 48 |
| Only NFC team never to have played in a Super Bowl | 50 |
| Only NBA player to shoot at least 50% on field goals, 40% on three-pointers and 90% on free throws for five consecutive seasons | 127 |
| Only native Englishman ever named Doctor of the Church by a pope | 64 |
| Only nation with a Caspian and Indian Ocean coastline | 53 |
| Only N.L. pitcher to win four Cy Young Awards | 45 |
| Only murderer to be named Super Bowl MVP | 40 |
| Only Mouseketeer personally chosen by Walt Disney | 49 |
| Only monosyllabic state | 23 |
| Only money accepted at the Sky Mall? | 36 |
| Only mo. that can start and end on the same day | 47 |
| Only mo. that can begin and end on the same day | 47 |
| Only mo. all four major sports are played | 41 |
| Only MLB'er to hit 60 homers thrice | 39 |
| Only minimally | 14 |
| Only million-selling Beatles single that was a cover | 52 |
| Only metal that's liquid at room temperature | 48 |
| Only Met ever to have a 30-game hitting streak | 46 |
| Only men's basketball coach to lead three different schools to the NCAA Final Four | 86 |
| Only member of both OPEC and the British Commonwealth | 53 |
| Only man to win two tennis Grand Slams | 38 |
| Only man to win both a Nobel Prize and an Oscar | 47 |
| Only man to twice win the U.S. Open without losing a set in the entire tournament | 81 |
| Only man to fly in Mercury, Gemini and Apollo missions | 54 |
| Only man to be U.S. President and Chief Justice | 47 |
| Only man ever to win an L.P.G.A. Tour tournament (1962) | 55 |
| Only mammal with horns made of keratin | 38 |
| Only male singles Career Golden Slam winner | 43 |
| Only making the grade? | 22 |
| Only make-believe | 17 |
| Only major U.S. city with a radio station whose call letters spell the city's name | 86 |
| Only major tourney that Sam Snead failed to win | 47 |
| Only major "MASH" character played by the same actor in the film and TV series | 88 |
| Only look | 9 |
| Only Literature Nobelist also to win an Oscar | 45 |
| Only last name shared by two different Best Actor Oscar winners | 63 |
| Only key Irving Berlin composed in | 34 |
| Only just managed, with "out" | 39 |
| Only just managed (with "out") | 40 |
| Only just broke the tape | 24 |
| Only just | 9 |
| Only Japanese MLB player to pitch a no-hitter (he had two) | 58 |
| Only insects that can turn their heads to look behind them | 58 |
| Only Indonesian-speaking President | 34 |
| Only inanimate zodiac sign | 26 |
| Only inanimate zodiac representation | 36 |
| Only in the past | 16 |
| Only if it's worth the trade-off | 36 |
| Only hypothetical | 17 |
| Only host country to win the Women's World Cup | 50 |
| Only horse to defeat Man o' War | 35 |
| Only horse to beat Man o' War | 33 |