| One hoping for a big catch | 26 |
| Office location since 1800 | 26 |
| One portion of the laundry | 26 |
| Oater "Hold it!" | 26 |
| Oversized audio component? | 26 |
| One at the end of the line | 26 |
| Ones likely to chicken out | 26 |
| Options for tying neckties | 26 |
| Oenologist's specialty | 26 |
| Oenologist's expertise | 26 |
| One may be used in a sting | 26 |
| Oshkosh's state: Abbr. | 26 |
| Observe a football player? | 26 |
| Org. with Lynx and Mercury | 26 |
| One without a Y chromosome | 26 |
| One with two X chromosomes | 26 |
| Output from an old printer | 26 |
| One with candy and flowers | 26 |
| Olympian's achievement | 26 |
| Omicrons' predecessors | 26 |
| One way to extract a tooth | 26 |
| One-named New Age musician | 26 |
| Opening at a long lecture? | 26 |
| Opposite of 'nope' | 26 |
| One response to a proposal | 26 |
| One of two opposing forces | 26 |
| One calling at peak times? | 26 |
| Over there, to Shakespeare | 26 |
| One of a 1980s demographic | 26 |
| Org. for female fellowship | 26 |
| Object of Link's quest | 26 |
| Obsolescent storage device | 26 |
| Organisms, in combinations | 26 |
| One of Superman's foes | 26 |
| Online expression of shock | 26 |
| Org. concerned with suits | 25 |
| Org. popular with authors | 25 |
| One giving prior consent? | 25 |
| Old ___ (Civil War eagle) | 25 |
| Obey, with "by" | 25 |
| On a plane, train, or bus | 25 |
| One may come on the river | 25 |
| One who nails a test, say | 25 |
| One not allowing a volley | 25 |
| Oldenburg "oh!" | 25 |
| Oberhausen "oh" | 25 |
| One struck Chicken Little | 25 |
| Oak product ... or source | 25 |
| Oak leaf cluster features | 25 |
| One of Pooh's hundred | 25 |
| Org. concerned with decay | 25 |
| Org. on a toothpaste tube | 25 |
| Occlusion seminar sponsor | 25 |
| Org. for bridge builders? | 25 |
| Oil-well capper Red _____ | 25 |
| One of the Ponderosa boys | 25 |
| On ___ (out with someone) | 25 |
| On __ (counting calories) | 25 |
| Ore seeker's entrance | 25 |
| One requesting in earnest | 25 |
| One way to become parents | 25 |
| One selling TV time, e.g. | 25 |
| Old enough to know better | 25 |
| Offer one's knowledge | 25 |
| Old animated heroine Flux | 25 |
| Oxygen-dependent organism | 25 |
| Oxygen-dependent creature | 25 |
| Oxygen-consuming organism | 25 |
| Odin, Thor, Balder et al. | 25 |
| One place to worship from | 25 |
| One way you can say that? | 25 |
| Open-mouthed in amazement | 25 |
| One who works so you work | 25 |
| One may be double or free | 25 |
| One acting on your behalf | 25 |
| Ottoman potentates (Var.) | 25 |
| Opposed to, in the sticks | 25 |
| Opposed, in the backwoods | 25 |
| Opposed to, to Gomer Pyle | 25 |
| Opposed to, nonstandardly | 25 |
| Opposed to, in Appalachia | 25 |
| Once more, Dogpatch-style | 25 |
| Once more in the country? | 25 |
| One of Nixon's vices? | 25 |
| Old Greek gathering place | 25 |
| Obsessed fictional whaler | 25 |
| Offshore attention-getter | 25 |
| Opera featuring elephants | 25 |
| Origin of a large terrier | 25 |
| Otherwise called, briefly | 25 |
| Of a feather, so to speak | 25 |
| One-time growth regulator | 25 |
| One of the Balkans: Abbr. | 25 |
| Okefenokee Swamp resident | 25 |
| Opening off a larger room | 25 |
| One way to cook spaghetti | 25 |
| Order at the Green Dragon | 25 |
| On the less blustery side | 25 |
| Oriole or Yankee, briefly | 25 |
| Olds discontinued in 2004 | 25 |