| Lead lines? | 11 |
| Lead male descriptor | 20 |
| Lead male or female | 19 |
| Lead monitor, for short | 23 |
| Lead off | 8 |
| Lead on | 7 |
| Lead on a court | 15 |
| Lead on Broadway | 16 |
| Lead or bit | 11 |
| Lead or cameo | 13 |
| Lead or copper, e.g. | 20 |
| Lead or eyebrow | 15 |
| Lead or heavy | 13 |
| Lead or zinc | 12 |
| Lead ore | 8 |
| Lead ore samples | 16 |
| Lead ores | 9 |
| Lead parts | 10 |
| Lead pellet-filled item used to weigh down scuba divers | 55 |
| Lead performer | 14 |
| Lead pilot's helper | 23 |
| Lead pilot's support | 24 |
| Lead plant | 10 |
| Lead player | 11 |
| Lead provider | 13 |
| Lead pumper | 11 |
| Lead pumper, in old slang | 25 |
| Lead rat in "Ratatouille" | 35 |
| Lead reducer | 12 |
| Lead role | 9 |
| Lead role in 'La Cage aux Folles' | 41 |
| Lead role in "A Chorus Line" | 38 |
| Lead role in "Clueless" | 33 |
| Lead role in "Die Meistersinger von Nürnberg" | 58 |
| Lead role in "Hawaii Five-O" | 38 |
| Lead role in "La Cage aux Folles" | 43 |
| Lead role in "Miracle on 34th Street" | 47 |
| Lead role in "The Piano" | 34 |
| Lead role in "The Vampire Diaries" | 44 |
| Lead role in a 1924 G.B. Shaw play | 34 |
| Lead role in a 60's TV drama | 32 |
| Lead role in a classic Arthur Miller play | 41 |
| Lead role in producers Max and Leo's musical | 48 |
| Lead role in Rimsky-Korsakov's "The Maid of Pskov" | 64 |
| Lead role in the film "La Cage aux Folles" | 52 |
| Lead role in the film known in France as "L'Or de la Vie" | 71 |
| Lead role on "Providence" | 35 |
| Lead role on TV's "Providence" | 44 |
| Lead seeker: Abbr. | 18 |
| Lead sharer | 11 |
| Lead singer | 11 |
| Lead singer for the Belmonts | 28 |
| Lead singer for The Wailers | 27 |
| Lead singer in No Doubt's hit "Don't Speak" | 61 |
| Lead singer in the band Heart | 29 |
| Lead singer Michaels of Poison | 30 |
| Lead singer of Buzzcocks | 24 |
| Lead singer of Led Zeppelin | 27 |
| Lead singer of Pearl Jam | 24 |
| Lead singer of rock's Foo Fighters | 38 |
| Lead singer of the band Body Count | 34 |
| Lead singer of the band whose name is derived from a "Barbarella" villain's name | 94 |
| Lead singer of The Cars | 23 |
| Lead singer of the Doors | 24 |
| Lead singer of the fictional Pussycats | 38 |
| Lead singer of the Irish rock group The Corrs | 45 |
| Lead singer of the Isley Brothers | 33 |
| Lead singer of the Kinks | 24 |
| Lead singer of the Main Ingredient | 34 |
| Lead singer of The Miracles | 27 |
| Lead singer of U2 | 17 |
| Lead singer on "Octopus's Garden" | 47 |
| Lead singer with Dawn | 21 |
| Lead singer with The Police | 27 |
| Lead singer's spot | 22 |
| Lead single from The Smashing Pumpkins' "Gish" | 60 |
| Lead Soprano | 12 |
| Lead Soprano? | 13 |
| Lead source | 11 |
| Lead speaker | 12 |
| Lead splitter | 13 |
| Lead statistic | 14 |
| Lead strip joining glass panes | 30 |
| Lead substitute | 15 |
| Lead sulfide | 12 |
| Lead the bidding | 16 |
| Lead the billing | 16 |
| Lead the cast | 13 |
| Lead the cast of | 16 |
| Lead the life of ___ | 20 |
| Lead the life ___ | 17 |
| Lead the meeting | 16 |
| Lead the nomad's life | 25 |
| Lead the orchestra | 18 |
| Lead the pack | 13 |
| Lead the pack, e.g. | 19 |
| Lead the way | 12 |
| Lead to | 7 |
| Lead to a result | 16 |
| Lead to a seat, informally | 26 |