| Substance used in perfumes | 26 |
| Substance used in treating acne | 31 |
| Substance used to curdle milk | 29 |
| Substance used to ignite firework fuses | 39 |
| Substance used to make ink | 26 |
| Substance used to protect or stabilize | 38 |
| Substance usually abbreviated | 29 |
| Substance whose synthesis required a "life force," alchemists believed | 80 |
| Substance with a historical museum in Amsterdam | 47 |
| Substance with a low pH | 23 |
| Substance with a pH higher than 7 | 33 |
| Substance written about in Jose Canseco's "Juiced" | 64 |
| Substance's partner | 23 |
| Substance, such as benzene | 26 |
| Substance-abusing star of "Mean Girls" in headlines | 61 |
| Substance-banning agcy. | 23 |
| Substances collectively called "the bad cholesterol" | 62 |
| Substances derived from nitrogen | 32 |
| Substances essential, in minute quantities, to nutrition | 56 |
| Substances for Strads | 21 |
| Substances in seams | 19 |
| Substances like water, vis-Ã -vis sugar | 41 |
| Substances sans liquid or gas | 29 |
| Substances similar in structure, in chemistry | 45 |
| Substances that make paint set more quickly | 43 |
| Substances that ooze out | 24 |
| Substances used by etchers | 26 |
| Substances used in chemical analysis | 36 |
| Substances used in soap | 23 |
| Substances with low pH | 22 |
| Substandard | 11 |
| Substandard contraction | 23 |
| Substandard effort | 18 |
| Substandard grade | 17 |
| Substandard item | 16 |
| Substandard language form | 25 |
| Substandard marks | 17 |
| Substantial | 11 |
| Substantial amounts | 19 |
| Substantial baby shower gift | 28 |
| Substantial bill | 16 |
| Substantial bit | 15 |
| Substantial bodies of work | 26 |
| Substantial content | 19 |
| Substantial entrees | 19 |
| Substantial food | 16 |
| Substantial hit: Abbr. | 22 |
| Substantial in scope, as a film | 31 |
| Substantial meal | 16 |
| Substantial meaning | 19 |
| Substantial plates | 18 |
| Substantial portion | 19 |
| Substantial repast | 18 |
| Substantial sandwich | 20 |
| Substantial serving of Preparation H, e.g. | 42 |
| Substantial shoe spec | 21 |
| Substantial slump | 17 |
| Substantial subs | 16 |
| Substantial sum | 15 |
| Substantial volume | 18 |
| Substantial, as a meal | 22 |
| Substantial, as a role | 22 |
| Substantial, as a sum | 21 |
| Substantial, as an amount | 25 |
| Substantial, as sums | 20 |
| Substantial, in slang | 21 |
| Substantial, sumwise | 20 |
| Substantially | 13 |
| Substantially (in) | 18 |
| Substantially fewer | 19 |
| Substantially removed (from) | 28 |
| Substantiate | 12 |
| Substantiated | 13 |
| Substantiates | 13 |
| Substantive | 11 |
| Substantive in grammar | 22 |
| Substantive part | 16 |
| Substantive substitutes | 23 |
| Substantives | 12 |
| Substitutable wd. | 17 |
| Substitute | 10 |
| Substitute (for) | 16 |
| Substitute a voice on a soundtrack | 34 |
| Substitute acquired by about half a million people a year: Abbr. | 64 |
| Substitute approved by the FDA in 1996 | 38 |
| Substitute at dinner | 20 |
| Substitute at the plate | 23 |
| Substitute at the stadium | 25 |
| Substitute bread spread | 23 |
| Substitute currency | 19 |
| Substitute decision? | 20 |
| Substitute dentist's activity? | 34 |
| Substitute doctors, in Britain | 30 |
| Substitute for | 14 |
| Substitute for a broken doorbell? | 33 |
| Substitute for a cart | 21 |
| Substitute for a forgotten lyric | 32 |
| Substitute for a jittery pilot? | 31 |
| Substitute for action | 21 |
| Substitute for an umbrella? | 27 |