| A serious one may be red | 24 |
| A serving of grog or rum | 24 |
| A Seven Sisters school | 22 |
| A seven-footer, quite often | 27 |
| A seventh-century date | 22 |
| A Shakespeare contemporary | 26 |
| A shark might give you one | 26 |
| A sharp, by another name | 24 |
| A Shaw who married a Gardner | 28 |
| A shelf in a kitchen cabinet? | 29 |
| A shepherd shepherds it | 23 |
| A shepherd, originally | 22 |
| A sheriff may be seen in it | 27 |
| A sheriff may round one up | 26 |
| A shift lever changes them | 26 |
| A ship may appear on it | 23 |
| A ship, to crew members | 23 |
| A shirt tag may tickle it | 25 |
| A shoe presses against it | 25 |
| A shogun may tie one on | 23 |
| A shooter might take it | 23 |
| A shooter takes it off | 22 |
| A shootout might end it | 23 |
| A short story, in Sept-Isles | 29 |
| A short, thickset haddock? | 26 |
| A shot in the arm, maybe | 24 |
| A shot in the arm, say | 22 |
| A shot might indicate it | 24 |
| A shuttlecock sails over it | 27 |
| A sibling of Cottontail | 23 |
| A side of the Big Apple | 23 |
| A sign of elation or optimism | 29 |
| A sign of things to come | 24 |
| A silent butler may hold it | 27 |
| A simpler one may be recalled | 29 |
| A single bounce, in baseball | 28 |
| A single might get you one | 26 |
| A single stroke under par | 25 |
| A single, in Stuttgart | 22 |
| A sister of Peter Rabbit | 24 |
| A sister of Terpsichore | 23 |
| A sister-in-law of Albany | 25 |
| A sister-in-law of Jacob | 24 |
| A sixth-century Dacia settler | 29 |
| A size too small, maybe | 23 |
| A slave to crosswords? | 22 |
| A sleeper hit may be on it | 26 |
| A slick, with or without pics | 29 |
| A slipcover might cover it | 26 |
| A slot machine has one | 22 |
| A small dog, for short | 22 |
| A small drink of liquor | 23 |
| A small, freshwater fish | 24 |
| A smash might smash into it | 27 |
| A smoker may flick it off | 25 |
| A smoker might bum one | 22 |
| A snake may swallow one whole | 29 |
| A snifter has a short one | 25 |
| A snooze under a sombrero | 25 |
| A socially correct goose? | 25 |
| A soft drink may have one | 25 |
| A soldier may swig from it | 26 |
| A soldier working in a mess? | 28 |
| A sole might get caught in it | 29 |
| A solid-colored billiard ball | 29 |
| A solo dinger counts for one | 28 |
| A sometimes-blonde, e.g. | 24 |
| A son of Aphrodite: Var. | 24 |
| A son of Bela: 1 Chr. 7:7 | 25 |
| A son of Cronus and Rhea | 24 |
| A son of Gad: Gen. 46:16 | 24 |
| A son of Hercules and Omphale | 29 |
| A son of Isaac and Rebecca | 26 |
| A son of Jacob and Leah | 23 |
| A son of Jacob and Zilpah | 25 |
| A son of Leah and Jacob | 23 |
| A son of Midian: I Chr. 1:33 | 28 |
| A son of Zeus and Hera | 22 |
| A sophomore or a junior, e.g. | 29 |
| A sore loser he isn't | 25 |
| A sound from the tower | 22 |
| A source of inks and paints | 27 |
| A source of mother-of-pearl | 27 |
| A source of oil and flour | 25 |
| A source of sugar and syrup | 27 |
| A source of the Mississippi | 27 |
| A South African capital | 23 |
| A south-of-the-border assent | 28 |
| A southern constellation | 24 |
| A Southern sodbuster ___ | 24 |
| A Soviet adm. division | 22 |
| A Spanish 21 deck has none | 26 |
| A Spanish queen and namesakes | 29 |
| A sPArkling brightness | 22 |
| A speaker might make it | 23 |
| A spire is part of one | 22 |
| A splitting, as of atoms | 24 |
| A sponge might have a big one | 29 |
| A spore is at its core | 22 |
| A spray might be used for one | 29 |