| Second City transportation agcy. | 32 |
| Second City specialty | 21 |
| Second city of the U.S. | 23 |
| Second city of Japan | 20 |
| Second choice | 13 |
| Second childhood | 16 |
| Second child | 12 |
| Second checkup | 14 |
| Second chances in school | 24 |
| Second chances for students | 27 |
| Second chances | 14 |
| Second chance, of a sort | 24 |
| Second chance in school | 23 |
| Second chance in education? | 27 |
| Second chance in court | 22 |
| Second chance for viewers | 25 |
| Second chance for couch potatoes | 32 |
| Second chance | 13 |
| Second cervical vertebra | 24 |
| Second century date | 19 |
| Second caution | 14 |
| Second careers for thoroughbreds | 32 |
| Second caliph | 13 |
| Second Bull Run victor | 22 |
| Second breakfast | 16 |
| Second book of the Torah | 24 |
| Second book of Pearl S. Buck's "Good Earth" trilogy | 65 |
| Second book of Moses: Abbr. | 27 |
| Second bk. of the Torah | 23 |
| Second biggest city in Russia's Orenburg region | 51 |
| Second best | 11 |
| Second beginning? | 17 |
| Second Beatles movie | 20 |
| Second Beatles film | 19 |
| Second baseman Santiago | 23 |
| Second baseman Sandberg | 23 |
| Second baseman Roberto | 22 |
| Second baseman of comedy | 24 |
| Second baseman Matsui, to fans | 30 |
| Second baseman Matsui | 21 |
| Second baseman in both of the Dodgers' 1980s World Series | 61 |
| Second baseman in a famed trio | 30 |
| Second baseman for the Big Red Machine | 38 |
| Second baseman called "The Crab" | 42 |
| Second baseman Boone | 20 |
| Second baseman Bobby whose #1 was retired by the Red Sox | 56 |
| SECOND BASEMAN | 14 |
| Second bananas | 14 |
| Second banana of a sort | 23 |
| Second banana in the kitchen | 28 |
| Second banana | 13 |
| Second ballot, often | 20 |
| Second avenue on a Monopoly board | 33 |
| Second audition | 15 |
| Second attempts | 15 |
| Second attempt to film | 22 |
| Second attempt at a phone call? | 31 |
| Second attempt | 14 |
| Second appearance on a soundtrack | 33 |
| Second and third in a sequence | 30 |
| Second American to fly in space | 31 |
| Second American in space | 24 |
| Second Amendment-touting gp. | 28 |
| Second Amendment-supporting gp. | 31 |
| Second Amendment word | 21 |
| Second Amendment verb | 21 |
| Second Amendment topic | 22 |
| Second Amendment supporters: Abbr. | 34 |
| Second Amendment supporter: Abbr. | 33 |
| Second Amendment supporter (Abbr.) | 34 |
| Second Amendment supporter | 26 |
| Second Amendment subject | 24 |
| Second Amendment rights org. | 28 |
| Second Amendment rights grp. | 28 |
| Second Amendment promoter: Abbr. | 32 |
| Second Amendment phrase | 23 |
| Second Amendment PAC | 20 |
| Second Amendment org. | 21 |
| Second Amendment lobby, for short | 33 |
| Second Amendment lobby | 22 |
| Second Amendment issue | 22 |
| Second Amendment grp. | 21 |
| Second Amendment defender: Abbr. | 32 |
| Second amendment concern | 24 |
| Second Amendment citing gp. | 27 |
| Second Amendment backer: Abbr. | 30 |
| Second Amendment advocates (abbr.) | 34 |
| Second Amendment advocate (abbr.) | 33 |
| Second Amendment advocacy grp. | 30 |
| Second Amendment advocacy gp. | 29 |
| Second Alice in Chains EP | 25 |
| Second album by AC/DC | 21 |
| Second airings | 14 |
| Second airing of a TV show | 26 |
| Second airing | 13 |
| Second afterthought: Abbr. | 26 |
| Second afterthought, in a ltr. | 30 |
| Second afterthought, for short | 30 |
| Second afterthought in a letter: Abbr. | 38 |
| Second afterthought (abbr.) | 27 |