| Second U.S. astronaut in space, after Alan Shepard | 50 |
| Second TV showing | 17 |
| Second try with Ali | 19 |
| Second try on a movie shot | 26 |
| Second Triumvirate member | 25 |
| Second trimester test, for short | 32 |
| Second tries, in cards | 22 |
| Second tries on the set | 23 |
| Second tries | 12 |
| Second trick | 12 |
| Second transactions | 19 |
| Second track on "Beatles '65" | 43 |
| Second to ___ (tops) | 20 |
| Second to ___ (the best) | 24 |
| Second to ___ | 13 |
| Second to __ (the best) | 23 |
| Second to __ | 12 |
| Second to none | 14 |
| Second time to the top | 22 |
| Second time around? | 19 |
| Second time around | 18 |
| Second three colors of rainbow | 30 |
| Second thoughts | 15 |
| Second thought leader | 21 |
| Second tel. line | 16 |
| Second Super Bowl won by the Redskins | 37 |
| Second Sunday of May honoree | 28 |
| Second Sunday in May honoree | 28 |
| Second Sunday before Lent | 25 |
| Second summer blockbuster film, e.g.: Abbr. | 43 |
| Second stringers | 16 |
| Second string | 13 |
| Second story? | 13 |
| Second story London visitor | 27 |
| Second story jobs | 17 |
| Second story | 12 |
| Second stories | 14 |
| Second stop in the Broadway song "We Open in Venice" | 62 |
| Second step in a three-step cleansing process | 45 |
| Second step for a marksman | 26 |
| Second step | 11 |
| Second starter? | 15 |
| Second starter | 14 |
| Second start? | 13 |
| Second start | 12 |
| Second star to be photographed | 30 |
| Second stabs | 12 |
| Second spin: close, but no cigar | 32 |
| Second spar | 11 |
| Second sound? | 13 |
| Second song on "Beatles '65" | 42 |
| Second son of the first man | 27 |
| Second son of Noah | 18 |
| Second son of Judah | 19 |
| Second son of Japheth | 21 |
| Second son of Jacob and Leah | 28 |
| Second son of Adam | 18 |
| Second son | 10 |
| Second something | 16 |
| Second sock, say | 16 |
| Second smallest Teletubby | 25 |
| Second smallest state: Abbr. | 28 |
| Second smallest of the U.S.A. | 29 |
| Second smallest continent, by size (abbr.) | 42 |
| Second smallest continent | 25 |
| Second Sister | 13 |
| Second sinner | 13 |
| Second sign on the music store door? | 36 |
| Second sign of a highway headache | 33 |
| Second sight, for short | 23 |
| Second sight, familiarly | 24 |
| Second sight, acronymi-cally | 28 |
| Second sight | 12 |
| Second side in a game, perhaps | 30 |
| Second showings | 15 |
| Second showing on TV | 20 |
| Second showing (1970) | 21 |
| Second showing | 14 |
| Second shots | 12 |
| Second shot, on a movie set | 27 |
| Second shot | 11 |
| Second shelf | 12 |
| Second sharp turn? | 18 |
| Second set, say | 15 |
| Second serve, for example | 25 |
| Second sequel's number | 26 |
| Second sequel tag | 17 |
| Second sequel notation | 22 |
| Second sequel indicator | 23 |
| Second sequel designation | 25 |
| Second self | 11 |
| Second section, perhaps | 23 |
| Second section or installment, perhaps | 38 |
| Second section | 14 |
| Second second thought, for short | 32 |
| Second SAC chief | 16 |
| Second run | 10 |
| Second row | 10 |
| Second Roman mo. | 16 |
| Second resolution | 17 |